Cytotoxicity of withanolides isolated from Acnistus arborescens

被引：38

作者：

Cordero, Claudia P. ^{[1
]}

Morantes, Sandra J. ^{[1
]}

Paez, Alexandra ^{[2
]}

Rincon, Javier ^{[2
]}

Aristizabal, Fabio A. ^{[1
]}

机构：

[1] Univ Nacl Colombia, Fac Ciencias, Dept Farm, Canc Pharmacogenet Res Grp, Bogota, DC, Colombia

[2] Univ Nacl Colombia, Fac Ciencias, Dept Farm, Bioact Principles Med Plants Res Grp, Bogota, DC, Colombia

来源：

FITOTERAPIA | 2009年 / 80卷 / 06期

关键词：

Withanolides; Acnistus arborescens; Solanaceae; In vitro cytotoxicity; WITHANIA-SOMNIFERA LEAVES; QUINONE REDUCTASE; ACTIVATION; INHIBITORS; WITHAFERIN; INDUCTION; APOPTOSIS; STEROIDS; GROWTH;

D O I：

10.1016/j.fitote.2009.05.011

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new withanolide identified by spectroscopic analysis as 12 beta-acetoxy-4-deoxy-5,6-deoxy-Delta(5)-withanolicle D and Withanolide D, were isolated from the leaves of Acnistus arborescens. Cytotoxic activity of these two compounds against human tumor cell lines HT-29, MCF-7, MKN-45, HEp-2, HeLa, U-937 and two human normal fibroblast cultures, Fib04 and Fib05, were assessed. Withanolide D presented in vitro cytotoxic activity against tumor cell lines at the low micromolar range (LC50:1.0 to 1.69 mu M) and showed a slightly lower activity against Fib04, suggesting moderated selectivity among tumoral and normal cells. No cytotoxic effect was observed for 12 beta-acetoxy-4-deoxy-5,6-deoxy-Delta(5)-withanolide D. (C) 2009 Published by Elsevier B.V.

引用

页码：364 / 368

页数：5

共 38 条

[1] Withanolides from Physalis peruviana [J].

Ahmad, S ;

Malik, A ;

Yasmin, R ;

Ullah, N ;

Gul, W ;

Khan, PM ;

Nawaz, HR ;

Afza, N .

PHYTOCHEMISTRY, 1999, 50 (04) :647-651

[2] WITHANOLIDES FROM IOCHROMA GESNERIOIDES [J].

ALFONSO, D ;

KAPETANIDIS, I .

PHYTOCHEMISTRY, 1994, 36 (01) :179-183

[3]

BARATA L, 1970, Anais da Academia Brasileira de Ciencias, V42, P401

[4] C-13 NMR-STUDIES .69. C-13 NMR-SPECTRA OF STEROIDS - SURVEY AND COMMENTARY [J].

BLUNT, JW ;

STOTHERS, JB .

ORGANIC MAGNETIC RESONANCE, 1977, 9 (08) :439-464

[5]

BRATATI D, 2003, FITOTERAPIA, V74, P14

[6] ANTI-MICROBIAL ACTIVITIES OF SOME ANTI-NEOPLASTIC AND OTHER WITHANOLIDES [J].

CHATTERJEE, S ;

CHAKRABORTI, SK .

ANTONIE VAN LEEUWENHOEK JOURNAL OF MICROBIOLOGY, 1980, 46 (01) :59-63

[7] Cholinesterase inhibiting withanolides from Withania somnifera [J].

Choudhary, MI ;

Yousuf, S ;

Nawaz, SA ;

Ahmed, S ;

Atta-ur-Rahman .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2004, 52 (11) :1358-1361

[8] Withanolides from Jaborosa laciniata [J].

Cirigliano, Adriana M. ;

Veleiro, Adriana S. ;

Misico, Rosana I. ;

Tettamanzi, Maria C. ;

Oberti, Juan C. ;

Burton, Gerardo .

JOURNAL OF NATURAL PRODUCTS, 2007, 70 (10) :1644-1646

[9]

CORDERO CP, 2002, REV COLOMB BIOTECNOL, V4, P100

[10]

FUSKA J, 1984, NEOPLASMA, V31, P31

← 1 2 3 4 →