Synthesis and Biological Evaluation of Heteroanalogues of Kotalanol and De-O-Sulfonated Kotalanol

被引：26

作者：

Mohan, Sankar ^{[1
]}

Jayakanthan, Kumarasamy ^{[1
]}

Nasi, Ravindranath ^{[1
]}

Kuntz, Douglas A. ^{[2
,3
]}

Rose, David R. ^{[2
,3
,4
]}

Pinto, B. Mario ^{[1
]}

机构：

[1] Simon Fraser Univ, Dept Chem, Burnaby, BC V5A 1S6, Canada

[2] Univ Toronto, Dept Med Biophys, Toronto, ON M5G 2M9, Canada

[3] Ontario Canc Inst, Div Mol & Struct Biol, Burnaby, BC V5A 1S6, Canada

[4] Univ Waterloo, Dept Biol, Waterloo, ON N2L 3G1, Canada

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 05期

关键词：

MEDICINE SALACIA-RETICULATA; SULFONIUM SULFATE STRUCTURE; HUMAN MALTASE GLUCOAMYLASE; GLYCOSIDASE INHIBITOR SALACINOL; OCCURRING GLUCOSIDASE INHIBITOR; CHAIN-EXTENDED HOMOLOGS; TRADITIONAL MEDICINE; ANALOGS; BLINTOL;

D O I：

10.1021/ol100080m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of nitrogen and selenium analogues of kotalanol and de-O-sulfonated kotalanol, naturally occurring sulfonium-ion glucosidase inhibitors isolated from Salacia reticulata, and their evaluation as glucosidase inhibitors against the N-terminal catalytic domain of human maltase glucoamylase (ntMGAM) are described.

引用

页码：1088 / 1091

页数：4

共 24 条

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MOHAN S, 2010, NAT PROD RE IN PRESS

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