Synthesis of isoxazolidines via catalyst-free one-pot three-component cycloaddition of sulfoxonium ylides, nitrosoarenes and alkenes

被引：28

作者：

Li, Xing ^{[1
]}

Zhai, Pingan ^{[1
]}

Fang, Yongsheng ^{[1
]}

Li, Wenhui ^{[1
]}

Chang, Honghong ^{[1
]}

Gao, Wenchao ^{[1
]}

机构：

[1] Taiyuan Univ Technol, Coll Biomed Engn, 79 West Yingze St, Taiyuan 030024, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2021年 / 8卷 / 05期

关键词：

ASYMMETRIC 1,3-DIPOLAR CYCLOADDITION; STEREOSELECTIVE-SYNTHESIS; BICYCLIC ISOXAZOLIDINES; NITRONE; CASCADE; ACCESS; ENHANCEMENT; ANNULATIONS; SELECTIVITY; GENERATION;

D O I：

10.1039/d0qo01471k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general and practical strategy for the construction of various keto-substituted isoxazolidines via one-pot three-component reaction of easily accessible, safer and more stable sulfoxonium ylides, nitrosoarenes and olefins is described. This three-component approach features remarkably much broader substrate scope, good functional group tolerance, good to high yields, operational safety and mild reaction conditions, and this method is also catalyst-free, additive-free and operationally simple.

引用

页码：988 / 995

页数：8

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