Bioactive dammarane-type triterpenoids derived from the acid hydrolysate of Gynostemma pentaphyllum saponins

被引：31

作者：

Bai, Ming-Sheng ^{[1
,2
,3
]}

Gao, Jin-Min ^{[1
,2
]}

Fan, Chen ^{[1
]}

Yang, Sheng-Xiang ^{[2
]}

Zhang, Gao ^{[4
]}

Zheng, Cheng-Dong ^{[1
,2
]}

机构：

[1] NW A&F Univ, Res Ctr Nat Med Chem, Coll Sci, Yangling 712100, Shaanxi, Peoples R China

[2] NW A&F Univ, Coll Life Sci, Yangling 712100, Shaanxi, Peoples R China

[3] Ningxia Univ, Coll Life Sci, Yinchuan 750021, Ningxia, Peoples R China

[4] Xian Inst Modern Chem, Ctr Anal & Detect, Xian 710065, Shaanxi, Peoples R China

来源：

FOOD CHEMISTRY | 2010年 / 119卷 / 01期

关键词：

Gynostemma pentaphyllum; Cucurbitaceae; Hydrolysate; Dammarane triterpenoid; Cytotoxicity; Porcine pancreatic lipase inhibitor; (23S)-3 beta-Hydroxydammar-20,24-dien-21-oic acid 21,23-lactone; NF-KAPPA-B; INHIBITION; ACTIVATION; GLYCOSIDES; APOPTOSIS; EXTRACT;

D O I：

10.1016/j.foodchem.2009.06.033

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

From an acid hydrolysate of the crude saponins of Gynostemma pentaphyllum, three triterpenes, including a new compound (23S)-3-beta-hydroxydammar-20,24-dien-21-oic acid 21,23-lactone (1) and two known aglycons (20S, 23R)-3 beta,20 beta-dihydroxydamma-24-dien-21-oic acid 21,23-lactone (2) and (20S, 24S)-20,24-epoxydammarane-3 beta,12 beta,25-triol(3), were isolated. Their structures were established on the basis of extensive spectral evidence (HR-ESI-MS, IR, 1D and 2D-NMR experiments). In bioactive assays in vitro, compound I was found to have potent cytotoxicity against the human breast cancer cells MDA-MB-435, whereas compounds 2 and 3 exhibited modest inhibitory activity toward porcine pancreatic lipase. The results indicated that acid treatment of G. pentaphyllum extract could produce diverse structures with interesting bioactivity. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：306 / 310

页数：5

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