Identification of Annexin A2 as a target protein for plant alkaloid matrine

被引：33

作者：

Wang, Dongyao ^{[1
]}

Cao, Yan ^{[1
]}

Zheng, Leyi ^{[1
]}

Lv, Diya ^{[1
]}

Chen, Langdong ^{[1
]}

Xing, Xinrui ^{[1
]}

Zhu, Zhenyu ^{[1
]}

Li, Xiaoyu ^{[2
]}

Chai, Yifeng ^{[1
]}

机构：

[1] Second Mil Med Univ, Sch Pharm, Shanghai, Peoples R China

[2] Univ Hong Kong, Dept Chem, Pokfulam Rd, Hong Kong, Hong Kong, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 36期

关键词：

TISSUE-PLASMINOGEN ACTIVATOR; ENDOTHELIAL-CELL RECEPTOR; CANCER-CELLS; PHOTOAFFINITY PROBES; APOPTOSIS; BINDING; MOLECULES; INVASION; PROLIFERATION; EXPRESSION;

D O I：

10.1039/c7cc02227a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Matrine is a plant alkaloid and a major active component in the Chinese medical herb Sophora flavescens. Matrine has shown potent anti-cancer activities but its molecular target(s) and mechanism are still unknown. Using the photo-affinity labeling approach, for the first time, Annexin A2 was identified as a direct-binding target of matrine in cancer cells.

引用

页码：5020 / 5023

页数：4

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