Streptococcus thermophilus ST28 Ameliorates Colitis in Mice Partially by Suppression of Inflammatory Th17 Cells

被引：27

作者：

Ogita, Tasuku ^{[1
]}

Nakashima, Megumi ^{[1
]}

Morita, Hidetoshi ^{[2
]}

Saito, Yasuo ^{[3
]}

Suzuki, Takuya ^{[1
]}

Tanabe, Soichi ^{[1
]}

机构：

[1] Hiroshima Univ, Grad Sch Biosphere Sci, Hiroshima 7398528, Japan

[2] Azabu Univ, Sch Vet Med, Sagamihara, Kanagawa 2525201, Japan

[3] Glico Dairy Prod Co Ltd, Tech Res Inst, Tokyo 1960021, Japan

来源：

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY | 2011年

关键词：

DEXTRAN SODIUM-SULFATE; DENDRITIC CELLS; INTESTINAL INFLAMMATION; TIGHT JUNCTION; BOWEL-DISEASE; IN-VIVO; PROBIOTICS; INDUCTION; ARTHRITIS; CYTOKINES;

D O I：

10.1155/2011/378417

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The effects of Streptococcus thermophilus ST28 on cytokine production by murine splenocytes stimulated with transforming growth factor-beta plus interleukin- (IL-) 6 were evaluated. The addition of ST28 significantly repressed IL-17 production compared to ATCC 19258 (type strain). ST28 also decreased the number of Th17 cells in the stimulated splenocytes. The anti-inflammatory effects of ST28 administration were evaluated in mice with colitis induced by dextran sodium sulphate (DSS). Oral treatment of mice with ST28 ameliorated the intestinal lesions by DSS. Upon DSS treatment, IL-17 production in lamina propria lymphocytes (LPLs) was induced, but ST28 significantly decreased its production. ST28 also decreased the percentage of Th17 cells in LPL from DSS-induced colitis. The present results imply that ST28 suppresses the Th17 response in inflamed intestines and would be useful in the treatment of Th17-mediated diseases, such as inflammatory bowel disease.

引用

页数：9

共 39 条

[1] Immunobiology of dendritic cells [J].

Banchereau, J ;

Briere, F ;

Caux, C ;

Davoust, J ;

Lebecque, S ;

Liu, YT ;

Pulendran, B ;

Palucka, K .

ANNUAL REVIEW OF IMMUNOLOGY, 2000, 18 :767-+

[2] Migration and maturation of human colonic dendritic cells [J].

Bell, SJ ;

Rigby, R ;

English, N ;

Mann, SD ;

Knight, SC ;

Kamm, MA ;

Stagg, AJ .

JOURNAL OF IMMUNOLOGY, 2001, 166 (08) :4958-4967

[3] Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology [J].

Buonocore, Sofia ;

Ahern, Philip P. ;

Uhlig, Holm H. ;

Ivanov, Ivaylo I. ;

Littman, Dan R. ;

Maloy, Kevin J. ;

Powrie, Fiona .

NATURE, 2010, 464 (7293) :1371-1375

[4] Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function [J].

Cario, E. ;

Gerken, G. ;

Podolsky, D. K. .

GASTROENTEROLOGY, 2007, 132 (04) :1359-1374

[5] Modulation of the immune response by probiotic strains in a mouse model of gluten sensitivity [J].

D'Arienzo, Rossana ;

Maurano, Francesco ;

Lavermicocca, Paola ;

Ricca, Ezio ;

Rossi, Mauro .

CYTOKINE, 2009, 48 (03) :254-259

[6] Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses [J].

Denning, Timothy L. ;

Wang, Yi-Chong ;

Patel, Seema R. ;

Williams, Ifor R. ;

Pulendran, Bali .

NATURE IMMUNOLOGY, 2007, 8 (10) :1086-1094

[7] Probiotics in pregnant women to prevent allergic disease: a randomized, double-blind trial [J].

Dotterud, C. K. ;

Storro, O. ;

Johnsen, R. ;

Oien, T. .

BRITISH JOURNAL OF DERMATOLOGY, 2010, 163 (03) :616-623

[8] Evidence for the use of probiotics and prebiotics in inflammatory bowel disease: a review of clinical trials [J].

Hedin, Charlotte ;

Whelani, Kevin ;

Lindsay, James O. .

PROCEEDINGS OF THE NUTRITION SOCIETY, 2007, 66 (03) :307-315

[9] Characterization of Interleukin-17-Producing Regulatory T Cells in Inflamed Intestinal Mucosa From Patients With Inflammatory Bowel Diseases [J].

Hovhannisyan, Zaruhi ;

Treatman, Jacquelyn ;

Littman, Dan R. ;

Mayer, Lloyd .

GASTROENTEROLOGY, 2011, 140 (03) :957-965

[10] Involvement of IL-17A in the pathogenesis of DSS-induced colitis in mice [J].

Ito, Reiko ;

Kita, Masakazu ;

Shin-Ya, Masaharu ;

Kishida, Tsunao ;

Urano, Atsuyo ;

Takada, Ryusuke ;

Sakagami, Junichi ;

Imanishi, Jiro ;

Iwakura, Yoichiro ;

Okanoue, Takeshi ;

Yoshikawa, Toshikazu ;

Kataoka, Keisho ;

Mazda, Osam .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 377 (01) :12-16

← 1 2 3 4 →