Variation in susceptibility to benznidazole in isolates derived from Trypanosoma cruzi parental strains

被引:50
作者
Veloso, VM
Carneiro, CM
Toledo, MJO
Lana, M
Chiari, E
Tafuri, WL
Bahia, MT
机构
[1] Univ Fed Ouro Preto, Escola Farm, ICEB, Dept Ciencias Biol, BR-35400000 Ouro Preto, MG, Brazil
[2] Univ Fed Ouro Preto, Escola Farm, Dept Anal Clin, BR-35400000 Ouro Preto, MG, Brazil
来源
MEMORIAS DO INSTITUTO OSWALDO CRUZ | 2001年 / 96卷 / 07期
关键词
chemotherapy; drug susceptibility; Trypanosoma cruzi; benznidazole;
D O I
10.1590/S0074-02762001000700021
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
In this work, the susceptibility to benznidazole of two parental Trypanosoma cruzi strains, Colombian and Berenice-78, was compared to isolates obtained from dogs infected with these strains for several years. In order to evaluate the susceptibility to benznidazole two groups of mice were infected with one of five distinct populations isolated from dogs as well as the two parental strains of T. cruzi. The first group was treated with benznidazole during the acute phase and the second remained untreated controls. The animals were considered cured when parasitological and serological tests remained persistently negative. Mice infected with the Colombian strain and its isolates Colombian (A and B) did not cure after treatment. On the other hand, all animals infected with Berenice-78 were cured by benznidazole treatment, However 100%, 50% and 70% of cure rates were observed in animals infected with the isolates Berenice-78 B, C and D, respectively. No significant differences were observed in serological profile of infected control groups, with all animals presenting high antibody levels. However, the ELISA test showed differences in serological patterns between mice inoculated with the different T. cruzi isolates and treated with benznidazole. This variability was dependent on the T. cruzi population used and seemed to be associated with the level of resistance to benznidazole.
引用
收藏
页码:1005 / 1011
页数:7
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