Isolation of avian paramyxovirus 1 from a patient with a lethal case of pneumonia

被引：31

作者：

Goebel, Scott J. ^{[1
,2
]}

Taylor, Jill ^{[1
,2
]}

Barr, Bradd C. ^{[3
]}

Kielm, Timothy E.

Castro-Malaspina, Hugo R. ^{[4
,5
]}

Hedvat, Cyrus V. ^{[4
,5
]}

Rush-Wilson, Kim A. ^{[1
,2
]}

Kelly, Cassandra D. ^{[1
,2
]}

Davis, Stephen W. ^{[1
,2
]}

Samsonoffl, William A. ^{[1
,2
]}

Hurst, Kelley R. ^{[1
,2
]}

Behr, Melissa J. ^{[1
,2
]}

Masters, Paul S. ^{[1
,2
]}

机构：

[1] Wadsworth Ctr, New York State Dept Hlth, David Axelrod Inst, Div Infect Dis, Albany, NY 12201 USA

[2] Wadsworth Ctr, New York State Dept Hlth, David Axelrod Inst, Div Mol Med, Albany, NY 12201 USA

[3] Univ Calif Davis, Sch Vet Med, California Anim Hlth & Food Safety Lab, Davis, CA 95616 USA

[4] Mem Sloan Kettering Canc Ctr, Dept Clin Labs Med, New York, NY 10021 USA

[5] Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA

来源：

JOURNAL OF VIROLOGY | 2007年 / 81卷 / 22期

关键词：

D O I：

10.1128/JVI.01406-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

An unknown virus was isolated from a lung biopsy sample and multiple other samples from a patient who developed a lethal case of pneumonia following a peripheral blood stem cell transplant. A random PCR-based molecular screening method was used to identify the infectious agent as avian paramyxovirus 1 (APMV-1; a group encompassing Newcastle disease virus), which is a highly contagious poultry pathogen that has only rarely been found in human infections. Immunohistochemical analysis confirmed the presence of APW-1 antigen in sloughed alveolar cells in lung tissue from autopsy. Sequence from the human isolate showed that it was most closely related to virulent pigeon strains of APW-1. This is the most completely documented case of a systemic human infection caused by APMV-1 and is the first report of an association between this virus and a fatal disease in a human.

引用

页码：12709 / 12714

页数：6

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