The AAOS Clinical Practice Guideline on osteochondritis dissecans of the knee presents few conclusive recommendations on the diagnosis and treatment of children and adults with stable and unstable lesions. Many different evaluation and treatment modalities have been used, although few in a prospective, randomized manner. The guideline does suggest using MRI to evaluate the lesion. However, all other recommendations are either inconclusive or required consensus grading. This guideline will serve as a roadmap for further investigation into this vexing condition.