Ceric ammonium nitrate (CAN): an efficient and eco-friendly catalyst for the one-pot synthesis of alkyl/aryl/heteroaryl-substituted bis(6-aminouracil-5-yl)methanes at room temperature

被引：44

作者：

Brahmachari, Goutam ^{[1
]}

Banerjee, Bubun ^{[1
]}

机构：

[1] Visva Bharati Univ, Dept Chem, Lab Nat Prod & Organ Synth, Santini Ketan 731235, W Bengal, India

来源：

RSC ADVANCES | 2015年 / 5卷 / 49期

关键词：

CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; MULTICOMPONENT REACTION; 4-COMPONENT SYNTHESIS; PYRIMIDINE-DERIVATIVES; RECYCLABLE CATALYST; RADICAL-ADDITION; INHIBITION; FACILE; ACID; SCAFFOLDS;

D O I：

10.1039/c5ra04723d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A simple, facile and convenient practical method for the one-pot synthesis of biologically relevant alkyl/aryl/heteroaryl-substituted bis(6-aminouracil-5-yl) methane scaffolds (3a-3u) has been developed using ceric ammonium nitrate (CAN) as a commercially available and eco-friendly catalyst via pseudo three-component condensation reaction between aldehydes and 6-aminouracils in aqueous ethanol at room temperature. The salient features of the present protocol are mild reaction conditions, good to excellent yields, high atom-economy, environmentally benignity, easy isolation of products, no column chromatographic separation and reusability of reaction media.

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页码：39263 / 39269

页数：7

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