Improved Synthesis of an Ascaroside Pheromone Controlling Dauer Larva Development in Caenorhabditis elegans

被引：5
|
作者：
Martin, Rene [1 ]
Schaefer, Tina [1 ]
Theumer, Gabriele [1 ]
Entchev, Eugeni V. [2 ]
Kurzchalia, Teymuras V. [2 ]
Knoelker, Hans-Joachim [1 ]
机构：
[1] Tech Univ Dresden, Dept Chem, D-01069 Dresden, Germany
[2] Max Planck Inst Mol Zellbiol & Genet, D-01307 Dresden, Germany
来源：
SYNTHESIS-STUTTGART | 2009年 / 20期
关键词：
carbohydrates; natural products; pheromones; stereoselective synthesis; Wacker reactions; UNPROTECTED GLYCOSYL DONORS; STEREOSELECTIVE-SYNTHESIS; LIFE-SPAN; DAF-12; ACID; RECEPTOR; LIGANDS;
D O I：
10.1055/s-0029-1216967
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Using an efficient Wacker oxidation as a key step, we describe a significantly improved synthesis of the dauer-promoting ascaroside 2 for biological studies of the novel sterol ring methylase STRM-1.
引用
收藏
页码：3488 / 3492
页数：5
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