Improved Synthesis of an Ascaroside Pheromone Controlling Dauer Larva Development in Caenorhabditis elegans

被引：5

作者：

Martin, Rene ^{[1
]}

Schaefer, Tina ^{[1
]}

Theumer, Gabriele ^{[1
]}

Entchev, Eugeni V. ^{[2
]}

Kurzchalia, Teymuras V. ^{[2
]}

Knoelker, Hans-Joachim ^{[1
]}

机构：

[1] Tech Univ Dresden, Dept Chem, D-01069 Dresden, Germany

[2] Max Planck Inst Mol Zellbiol & Genet, D-01307 Dresden, Germany

来源：

SYNTHESIS-STUTTGART | 2009年 / 20期

关键词：

carbohydrates; natural products; pheromones; stereoselective synthesis; Wacker reactions; UNPROTECTED GLYCOSYL DONORS; STEREOSELECTIVE-SYNTHESIS; LIFE-SPAN; DAF-12; ACID; RECEPTOR; LIGANDS;

D O I：

10.1055/s-0029-1216967

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Using an efficient Wacker oxidation as a key step, we describe a significantly improved synthesis of the dauer-promoting ascaroside 2 for biological studies of the novel sterol ring methylase STRM-1.

引用

页码：3488 / 3492

页数：5

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