Safety is becoming more and more important with the ever increasing level of safety related E/E Systems built into the cars. Increasing functionality of vehicle systems through electrification of power train and autonomous driving leads to complexity in designing system, software and safety architecture. ISO 26262 aims to reduce the complexity and to approve the traceability of the different safety activities. An approach, how the engineers deal with these challenges in an efficient and effective way, offers model-driven system, software and safety development. This makes it possible to describe, analyze and verify the system, software and safety architecture with models in order to detect the design and systematic errors before implementation. This paper presents an approach about model-based development of system, software and safety. In particular, we briefly discuss how the main activities from ISO 26262 such as hazard analysis and risk assessment, functional safety concept, technical safety concept, safety analysis, etc. can be developed model-driven and how it can be merged with system and software development. The state-of-art is also provided and compared with the proposed approach.