Severe Hemolytic Crisis After Ceftriaxone Administration

被引：16

作者：

Goyal, Monika ^{[1
]}

Donoghue, Aaron ^{[2
]}

Schwab, Sandra ^{[1
]}

Hasbrouck, Nicole ^{[3
]}

Khojasteh, Soreena ^{[4
]}

Osterhoudt, Kevin ^{[1
]}

机构：

[1] Univ Penn, Childrens Hosp Philadelphia, Sch Med, Div Emergency Med, Philadelphia, PA 19104 USA

[2] Univ Penn, Childrens Hosp Philadelphia, Sch Med, Div Emergency Med & Crit Care, Philadelphia, PA 19104 USA

[3] Univ Penn, Childrens Hosp Philadelphia, Sch Med, Div Hematol & Oncol, Philadelphia, PA 19104 USA

[4] Univ Penn, Childrens Hosp Philadelphia, Sch Med, Dept Pediat, Philadelphia, PA 19104 USA

来源：

PEDIATRIC EMERGENCY CARE | 2011年 / 27卷 / 04期

关键词：

sickle cell; hemolysis; ceftriaxone; adverse reaction;

D O I：

10.1097/PEC.0b013e3182131fa8

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Ceftriaxone is a commonly administered antibiotic, and hemolytic crisis is a dangerous potential adverse event. We describe 2 children with sickle cell disease who developed severe hemolytic crisis after ceftriaxone administration. Both subsequently demonstrated the presence of anticeftriaxone antibodies that may have been responsible for the massive hemolysis.

引用

页码：322 / 323

页数：2

共 3 条

[1] FATAL HEMOLYSIS INDUCED BY CEFTRIAXONE IN A CHILD WITH SICKLE-CELL-ANEMIA [J].

BERNINI, JC ;

MUSTAFA, MM ;

SUTOR, LJ ;

BUCHANAN, GR .

JOURNAL OF PEDIATRICS, 1995, 126 (05) :813-815

[2] Prevalence of ceftriaxone-induced red blood cell antibodies in pediatric patients with sickle cell disease and human immunodeficiency virus infection [J].

Quillen, Karen ;

Lane, Catherine ;

Hu, Edward ;

Pelton, Stephen ;

Bateman, Scot .

PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2008, 27 (04) :357-358

[3]

2002, MED LETT DRUGS THER, V44, P100

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