Interaction Between Autophagy and Porphyromonas gingivalis-Induced Inflammation

被引：6
作者：
Kang, Sen [1 ]
Dai, Anna [1 ]
Wang, Huiming [1 ]
Ding, Pei-Hui [1 ]
机构：
[1] Zhejiang Univ, Stomatol Hosp, Clin Res Ctr Oral Dis Zhejiang Prov,Sch Med, Sch Stomatol,Key Lab Oral Biomed Res Zhejiang Prov, Hangzhou, Zhejiang, Peoples R China
来源：
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2022年 / 12卷
基金：
中国国家自然科学基金;
关键词：
autophagy; Porphyromonas gingivalis; inflammation; xenophagy; macroautophagy; CYCLIC GMP-AMP; LIGHT-CHAIN; 3; REACTIVE OXYGEN; MYCOBACTERIUM-TUBERCULOSIS; PERIODONTAL PATHOGEN; BACTERIAL AUTOPHAGY; NLRP3; ACTIVATION; LYSOSOMAL DAMAGE; RECEPTOR NDP52; P2X7; RECEPTOR;
D O I：
10.3389/fcimb.2022.892610
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Autophagy is an immune homeostasis process induced by multiple intracellular and extracellular signals. Inflammation is a protective response to harmful stimuli such as pathogen microbial infection and body tissue damage. Porphyromonas gingivalis infection elicits both autophagy and inflammation, and dysregulation of autophagy and inflammation promotes pathology. This review focuses on the interaction between autophagy and inflammation caused by Porphyromonas gingivalis infection, aiming to elaborate on the possible mechanism involved in the interaction.
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页数：15
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