FKBP immunophilin patents for neurological disorders

被引：13
作者：
Babine, RE [1 ]
Villafranca, JE
Gold, BG
机构：
[1] Recovexx Pharmaceut Inc, San Diego, CA 92103 USA
[2] Oregon Hlth Sci Univ, Dept Neurol, Portland, OR 97239 USA
[3] Oregon Hlth Sci Univ, Ctr Res Occupat & Environm Toxicol, Portland, OR 97239 USA
来源：
EXPERT OPINION ON THERAPEUTIC PATENTS | 2005年 / 15卷 / 05期
关键词：
FK-506; FKBP; FKBP-12; FKBP-52; immunophilin; neurodegenerative disease; tacrolimus; rapamycin;
D O I：
10.1517/13543776.15.5.555
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Immunophilins are a family of binding proteins that are highly conserved in nature and mediate the actions of immunosuppressant drugs. The FK-506-binding protein (FKBP) subclass of immunophilin bind FK-506 and rapamycin and are of particular interest due to their potent neurotrophic activity. Here, the patent literature covering the structures of novel non-immunosuppressant derivatives of FK-506 and rapamycin, and their claims pertaining to their potential use for the treatment of neurological disorders, are reviewed.
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收藏
页码：555 / 573
页数：19
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