The hypoxia-inducible factors: key transcriptional regulators of hypoxic responses

被引：207
作者：
Bracken, CP
Whitelaw, ML
Peet, DJ [1 ]
机构：
[1] Univ Adelaide, Dept Mol Biosci, Adelaide, SA 5005, Australia
[2] Univ Adelaide, Ctr Mol Genet Dev, Adelaide, SA 5005, Australia
来源：
CELLULAR AND MOLECULAR LIFE SCIENCES | 2003年 / 60卷 / 07期
关键词：
oxygen; hypoxia; hypoxia-inducible factor; bHLH/PAS; transcription; hydroxylation;
D O I：
10.1007/s00018-003-2370-y
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Oxygen depravation in mammals leads to the transcriptional induction of a host of target genes to metabolically adapt to this deficiency, including erythropoietin and vascular endothelial growth factor. This response is primarily mediated by the hypoxia-inducible factors (HIFs) which are members of the basic-helix-loop-helix/Per-ARNT-Sim (bHLH/PAS) transcription factor family. The HIFs are primarily regulated via a two-step mechanism of HIF post-translational modification, increasing both protein stability and transactivation capacity. This review aims to summarise our current understanding of these processes, and discuss the important role of the HIFs in the pathophysiology of many human diseases.
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收藏
页码：1376 / 1393
页数：18
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