Fibroadenoma in vulval ectopic breast tissue in a patient with PTEN Hamartoma Tumour Syndrome

被引：1

作者：

Dawson, Hannah ^{[1
]}

Smrke, Alannah ^{[1
]}

Ellery, Peter M. ^{[2
]}

Wilkinson, Nafisa ^{[2
]}

Rosenthal, Adam N. ^{[3
]}

McVeigh, Terri P. ^{[1
]}

机构：

[1] Royal Marsden Hosp NHS Fdn Trust, 203 Fulham Rd, London SW3 6JJ, England

[2] Univ Coll London Hosp NHS Fdn Trust, Dept Cellular Pathol, London, England

[3] UCL, Inst Womens Hlth, Dept Womens Canc, London, England

来源：

FAMILIAL CANCER | 2022年 / 21卷 / 03期

关键词：

PTEN; Cowden syndrome; Vulval fibroadenoma; Ectopic breast tissue; PTEN hamartoma tumour syndrome; GENOTYPE-PHENOTYPE CORRELATIONS; MAMMARY-LIKE GLANDS; COWDEN SYNDROME; CANCER; MUTATION; DISEASE; RISKS; GENE;

D O I：

10.1007/s10689-021-00275-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

PTEN is a tumour suppressor gene involved in regulating cell division. Pathogenic germline variants in PTEN predispose to benign and malignant growths of numerous organs, including of the breast. In the following report, we describe the first documented case of a fibroadenoma developing in ectopic breast tissue of the vulva in a patient with a germline pathogenic variant in PTEN. This highlights the risk of hyperplasia developing in any breast tissue, including rare ectopic sites, particularly in patients with underlying germline variants in cancer susceptibility genes.

引用

页码：363 / 368

页数：6

共 38 条

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