A reproductive and developmental screening study of the fungal toxin ochratoxin A in Fischer rats

被引:14
作者
Bondy, Genevieve S. [1 ]
Coady, Laurie [1 ]
Ross, Nikia [1 ]
Caldwell, Don [1 ]
Gannon, Anne Marie [1 ]
Kwong, Keri [2 ]
Hayward, Stephen [3 ]
Lefebvre, David E. [1 ]
Liston, Virginia [1 ]
Raju, Jayadev [1 ]
Pantazopoulos, Peter [2 ]
Curran, Ivan [1 ]
机构
[1] Hlth Canada, Bur Chem Safety, Food Directorate, Hlth Prod & Food Branch, Ottawa, ON K1A 0K9, Canada
[2] Hlth Canada, Ontario Food Lab, Labs Directorate, Regulatory Operat & Reg Branch, 2301 Midland Ave, Toronto, ON M1P 4R7, Canada
[3] Hlth Canada, Bur Food Surveillance & Sci Integrat, Food Directorate, Hlth Prod & Food Branch, Ottawa, ON K1A 0K9, Canada
关键词
Fetotoxic; Kidney; Ochratoxin A; Rat; Reproduction; NONPROLIFERATIVE LESIONS; IMMUNE-SYSTEM; RISK-ASSESSMENT; WISTAR RATS; EXPOSURE; MOUSE; TOXICITY; MICE; MYCOTOXINS;
D O I
10.1007/s12550-018-0319-0
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The presence of the mycotoxin ochratoxin A (OTA) in cereal grains is due to the growth of toxigenic Penicillium mold on stored crops. Human exposure to OTA is higher in infants, toddlers, and children than in adolescents and adults, based on exposure assessments of ng OTA consumed/kg body weight/day. Ochratoxin A is nephrotoxic and teratogenic in animals, but its effects on juveniles exposed during the reproduction and development period have not been studied. To address this, Fischer rats were exposed to 0, 0.16, 0.4, 1.0, or 2.5 mg OTA/kg diet throughout breeding, gestation, and lactation and its adverse effects were assessed in adult rats and their offspring on postnatal day (PND) 21. There were no effects on implantation but post-implantation fetotoxicity was observed in the 2.5 mg/kg dose group, corresponding to a calculated dose of 167 mu g/kg bw/day in dams. Adverse effects on body and kidney weights and on clinical parameters indicative of renal toxicity were significant in adult rats exposed to 1.0 mg OTA/kg diet (55.2 and 73.3 mu g/kg bw/day in adult males and females, respectively) and in PND21 rats at the 0.4 mg/kg dose (33.9 mu g/kg bw/day in dams), suggesting that weanling rats were more sensitive to OTA than adults. Overall, nephrotoxicity was the primary effect of OTA in weanling rats exposed throughout gestation and lactation at sub-fetotoxic concentrations in diet.
引用
收藏
页码:241 / 255
页数:15
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