Synthesis and Antiviral Evaluation of 3′-Fluoro-4′-modified-5′-norcarbocyclic Nucleoside Phosphonates

被引：3

作者：

Geant, Pierre-Yves ^{[1
]}

Kaci, Malika ^{[1
]}

Uttaro, Jean-Pierre ^{[1
]}

Perigaud, Christian ^{[1
]}

Mathe, Christophe ^{[1
]}

机构：

[1] Univ Montpellier, CNRS, UMR 5247, ENSCM,IBMM, Cc 1705,Site Triolet,Pl Eugene Bataillon, F-34095 Montpellier 5, France

来源：

CHEMMEDCHEM | 2019年 / 14卷 / 05期

关键词：

3 '-fluoro-5 '-norcarbocyclic nucleosides; anti-HIV; antiviral agents; phosphonates; HIV; ANALOGS;

D O I：

10.1002/cmdc.201800804

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and anti-HIV evaluation of hitherto unknown 3 '-fluoro-5 '-norcarbocyclic nucleoside phosphonates bearing adenine with modifications at the 4 ' position (ethynyl, vinyl, ethyl, hydroxymethyl) is described. One of the synthesized compounds was found to be an inhibitor of HIV-1 replication, but with moderate efficiency relative to (R)-9-(2-phosphonylmethoxypropyl)adenine ((R)-PMPA, tenofovir), with no concomitant cytotoxicity.

引用

页码：522 / 526

页数：5

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