Dendrimer-based molecular imaging contrast agents

被引：132

作者：

Qiao, Zheng ^{[1
,2
]}

Shi, Xiangyang ^{[1
,2
,3
]}

机构：

[1] Donghua Univ, Coll Chem Chem Engn & Biotechnol, Shanghai 201620, Peoples R China

[2] Univ Madeira, Ctr Quim Madeira, P-9000390 Funchal, Portugal

[3] Donghua Univ, State Key Lab Modificat Chem Fibers & Polymer Mat, Shanghai 201620, Peoples R China

来源：

PROGRESS IN POLYMER SCIENCE | 2015年 / 44卷

基金：

中国国家自然科学基金;

关键词：

Dendrimers; Molecular imaging; Contrast agents; Organic/inorganic nanohybrids; Radionuclide-based imaging; Cancer diagnosis; ENTRAPPED GOLD NANOPARTICLES; IRON-OXIDE NANOPARTICLES; X-RAY ATTENUATION; FACILE HYDROTHERMAL SYNTHESIS; MODALITY MAGNETIC-RESONANCE; COMPUTED-TOMOGRAPHY; STABILIZED GOLD; PAMAM-DENDRIMER; DRUG-DELIVERY; BIOMEDICAL APPLICATIONS;

D O I：

10.1016/j.progpolymsci.2014.08.002

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

This review reports recent advances on the use of dendrimer nanotechnology to build up various contrast agents for different single-mode or dual-mode molecular imaging applications. The versatile dendrimer scaffolds with 3-dimensional spherical shape, highly branched internal cavity, and tunable surface conjugation chemistry enable the facile modification of dendrimer surface with different imaging agents (e.g., fluorescent dyes, traditional small molecular contrast agents, or metal ion/chelator complexes) and targeting ligands, and convenient entrapment, stabilization, and self-assembly to form various organic or organic/inorganic hybrid nanoparticles that can be used as multifunctional contrast agents for both non-radionuclide- and radionuclide-based molecular imaging applications. In particular, strategies used to generate multifunctional nanoprobes for different modes of targeted molecular imaging of cancer are discussed in detail. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：1 / 27

页数：27

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