Surmounting Chemoresistance by Targeting the Y-Box Binding Protein-1

被引：11

作者：

Inoue, Ikuyo ^{[1
]}

Matsumoto, Ken ^{[2
]}

Yu, Yingnan ^{[1
]}

Bay, Boon-Huat ^{[1
]}

机构：

[1] Natl Univ Singapore, Yong Loo Lin Sch Med, Natl Univ Hlth Syst, Dept Anat, Singapore 117595, Singapore

[2] Inst Phys & Chem Res RIKEN, Lab Mol Entomol, Wako, Saitama, Japan

来源：

ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY | 2012年 / 295卷 / 02期

基金：

英国医学研究理事会;

关键词：

Y-box binding protein 1; cancer therapy; chemoresistance; TRANSCRIPTION FACTOR YB-1; INCREASED NUCLEAR-LOCALIZATION; BREAST-CANCER CELLS; COLD-SHOCK DOMAIN; P-GLYCOPROTEIN; MOLECULAR-MECHANISMS; ENHANCED EXPRESSION; DRUG-RESISTANCE; DNA-DAMAGE; ONE ALLELE;

D O I：

10.1002/ar.22401

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

The Y-box binding protein 1 (YB-1), characterized by the presence of the cold shock domain, has been reported to induce chemoresistance in cancer therapy. Chemotherapy is one of the main therapeutic strategies in the treatment of cancer, in addition to surgery, radiation therapy, and hormonal therapy. However, chemoresistance remains a key obstacle to successful cancer management. In this review, we will focus on the role of YB-1, an important regulator of gene transcription, in cancer therapy and chemoresistance. Anat Rec, 2012. (C) 2011 Wiley Periodicals, Inc.

引用

页码：215 / 222

页数：8

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