Vasoprotective activity of standardized Achillea millefolium extract

被引：38
作者：
Dall'Acqua, Stefano [1 ]
Bolego, Chiara [2 ]
Cignarella, Andrea [2 ]
Gaion, Rosa Maria [2 ]
Innocenti, Gabbriella [1 ]
机构：
[1] Univ Padua, Dipartimento Sci Farmaceut, I-35131 Padua, Italy
[2] Univ Padua, Dipartimento Farmacol & Anestesiol, I-35131 Padua, Italy
来源：
PHYTOMEDICINE | 2011年 / 18卷 / 12期
关键词：
Achillea millefolium; Phenolic derivatives; Anti-inflammatory activity; Vascular cells; ESTROGEN; INFLAMMATION; INHIBITION; CELLS;
D O I：
10.1016/j.phymed.2011.05.005
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
We investigated the effects of Achillea millefolium extract in vitro on the growth of primary rat vascular smooth muscle cells (VSMCs) as well as the potential involvement of estrogen receptors (ERs) in this process. In addition, the ability of A. millefolium extract to modulate the NF-kappa B pathway was tested in human umbilical vein endothelial cells (HUVECs). The fingerprinting of the extract was carried out by HPLC-DAD and LC-MSn and main constituents were flavonoids (10%) and dicaffeolylquinic acid derivatives (12%). The extract enhanced VSMC growth at least in part by acting through ERs and impaired NF-kappa B signaling in HUVECs. The various compounds may act with different mode of actions thus contributing to the final effect of the extract. Our findings support some of the traditional uses of A. millefolium, and suggest potential modes of action as related to its effects on vascular inflammation. Therefore, A. millefolium may induce novel potential actions in the cardiovascular system. (C) 2011 Elsevier GmbH. All rights reserved.
引用
收藏
页码：1031 / 1036
页数：6
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