Olfactory and Gustatory Dysfunction as an Early Identifier of COVID-19 in Adults and Children: An International Multicenter Study

被引：1

作者：

Qiu, Chenghao ^{[1
]}

Cui, Chong ^{[2
,3
,4
]}

Hautefort, Charlotte ^{[5
]}

Haehner, Antje ^{[6
]}

Zhao, Jun ^{[7
]}

Yao, Qi ^{[8
]}

Zeng, Hui ^{[9
]}

Nisenbaum, Eric J. ^{[10
]}

Liu, Li ^{[11
]}

Zhao, Yu ^{[2
,3
,4
]}

Zhang, Di ^{[12
]}

Levine, Corinna G. ^{[10
]}

Cejas, Ivette ^{[10
]}

Dai, Qi ^{[2
,3
,4
]}

Zeng, Mei ^{[13
]}

Herman, Philippe ^{[5
]}

Jourdaine, Clement ^{[5
]}

de With, Katja ^{[14
]}

Draf, Julia ^{[6
]}

Chen, Bing ^{[2
,3
,4
]}

Jayaweera, Dushyantha T. ^{[15
]}

Denneny, James C. ^{[16
]}

Casiano, Roy ^{[10
]}

Yu, Hongmeng ^{[2
,3
,4
]}

Eshraghi, Adrien A. ^{[10
]}

Hummel, Thomas ^{[6
]}

Liu, Xuezhong ^{[10
]}

Shu, Yilai ^{[2
,3
,4
]}

Lu, Hongzhou ^{[11
]}

机构：

[1] Shanghai Publ Hlth Clin Ctr, Ctr Stomatol, Shanghai, Peoples R China

[2] Fudan Univ, ENT Inst, Shanghai, Peoples R China

[3] Fudan Univ, Otorhinolaryngol Dept, Affiliated Eye & ENT Hosp, State Key Lab Med Neurobiol,Inst Biomed Sci, Shanghai, Peoples R China

[4] Fudan Univ, NHC Key Lab Hearing Med, Shanghai, Peoples R China

[5] Univ Paris, Dept Head & Neck Surg, Hop Lariboisiere, Paris, France

[6] Tech Univ Dresden, Dept Otorhinolaryngol, Smell & Taste Clin, Dresden, Germany

[7] Shanghai Publ Hlth Clin Ctr, Ctr Pediat, Shanghai, Peoples R China

[8] Huazhong Univ Sci & Technol, Chinese & Western Med Hosp, Dept Otorhinolaryngol, Tongji Med Coll, Wuhan, Peoples R China

[9] Third Peoples Hosp Shenzhen, Dept Cardiovascularol, Shenzhen, Peoples R China

[10] Univ Miami, Miller Sch Med, Dept Otolaryngol, Miami, FL 33136 USA

[11] Shanghai Publ Hlth Clin Ctr, Dept Infect Dis, 2901 Caolang Rd, Shanghai 201508, Peoples R China

[12] Third Peoples Hosp Shenzhen, Dept Otolaryngol, Shenzhen, Peoples R China

[13] Fudan Univ, Dept Infect Dis, Childrens Hosp, Shanghai, Peoples R China

[14] Tech Univ Dresden, Div Infect Dis, Univ Hosp Carl Gustav Carus, Dresden, Germany

[15] Univ Miami, Miller Sch Med, Dept Med, Div Infect Dis, Miami, FL 33136 USA

[16] Amer Acad Otolaryngol Head & Neck Surg, Alexandria, VA USA

来源：

OTOLARYNGOLOGY-HEAD AND NECK SURGERY | 2020年 / 163卷 / 04期

基金：

中国国家自然科学基金;

关键词：

COVID-19; SARS-CoV-2; anosmia; dysgeusia; screening; olfactory dysfunction; gustatory dysfunction;

D O I：

10.1177/0194599820934376

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Objective. To evaluate the prevalence and characteristics of olfactory or gustatory dysfunction in coronavirus disease 2019 (COVID-19) patients. Study Design. Multicenter case series. Setting. Five tertiary care hospitals (3 in China, 1 in France, 1 in Germany). Subjects and Methods. In total, 394 polymerase chain reaction (PCR)-confirmed COVID-19-positive patients were screened, and those with olfactory or gustatory dysfunction were included. Data including demographics, COVID-19 severity, patient outcome, and the incidence and degree of olfactory and/or gustatory dysfunction were collected and analyzed. The Questionnaire of Olfactory Disorders (QOD) and visual analog scale (VAS) were used to quantify olfactory and gustatory dysfunction, respectively. All subjects at 1 hospital (Shanghai) without subjective olfactory complaints underwent objective testing. Results. Of 394 screened subjects, 161 (41%) reported olfactory and/or gustatory dysfunction and were included. Incidence of olfactory and/or gustatory disorders in Chinese (n = 239), German (n = 39), and French (n = 116) cohorts was 32%, 69%, and 49%, respectively. The median age of included subjects was 39 years, 92 of 161 (57%) were male, and 10 of 161 (6%) were children. Of included subjects, 10% had only olfactory or gustatory symptoms, and 19% had olfactory and/or gustatory complaints prior to any other COVID-19 symptom. Of subjects with objective olfactory testing, 10 of 90 demonstrated abnormal chemosensory function despite reporting normal subjective olfaction. Forty-three percent (44/102) of subjects with follow-up showed symptomatic improvement in olfaction or gustation. Conclusions. Olfactory and/or gustatory disorders may represent early or isolated symptoms of severe acute respiratory syndrome coronavirus 2 infection. They may serve as a useful additional screening criterion, particularly for the identification of patients in the early stages of infection.

引用

页码：714 / 721

页数：8

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