Ultraviolet B-Induced Maturation of CD11b-Type Langerin- Dendritic Cells Controls the Expansion of Foxp3+ Regulatory T Cells in the Skin

被引：28
|
作者：
Yamazaki, Sayuri [1 ]
Odanaka, Mizuyu [1 ]
Nishioka, Akiko [2 ]
Kasuya, Saori [2 ]
Shime, Hiroaki [1 ]
Hemmi, Hiroaki [3 ,4 ]
Imai, Masaki [1 ]
Riethmacher, Dieter [5 ,6 ]
Kaisho, Tsuneyasu [3 ,4 ]
Ohkura, Naganari [7 ,8 ]
Sakaguchi, Shimon [7 ]
Morita, Akimichi [2 ]
机构：
[1] Nagoya City Univ, Dept Immunol, Grad Sch Med Sci, Nagoya, Aichi 4678601, Japan
[2] Nagoya City Univ, Dept Geriatr & Environm Dermatol, Grad Sch Med Sci, Nagoya, Aichi 4678601, Japan
[3] Wakayama Med Univ, Inst Adv Med, Dept Immunol, Wakayama 6418509, Japan
[4] Osaka Univ, World Premier Int Res Ctr Initiat, Immunol Frontier Res Ctr, Lab Immune Regulat, Osaka 5650871, Japan
[5] Nazarbayev Univ, Sch Med, Dept Biomed Sci, Astana 010000, Kazakhstan
[6] Univ Southampton, Sch Med, Southampton SO17 1BJ, Hants, England
[7] Osaka Univ, Dept Expt Immunol, World Premier Int Res Ctr Initiat, Immunol Frontier Res Ctr, Suita, Osaka 5650871, Japan
[8] Osaka Univ, Grad Sch Med, Dept Frontier Res Tumor Immunol, Ctr Med Innovat & Translat Res, Suita, Osaka 5650871, Japan
来源：
JOURNAL OF IMMUNOLOGY | 2018年 / 200卷 / 01期
基金：
日本学术振兴会;
关键词：
EPIDERMAL LANGERHANS CELLS; IN-VIVO; LYMPH-NODE; HOMEOSTASIS; MACROPHAGES; RADIATION; ABLATION; DISTINCT; DIFFERENTIATION; IRRADIATION;
D O I：
10.4049/jimmunol.1701056
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Skin dendritic cells (DCs) are divided into several subsets with distinctive functions. This study shows a previously unappreciated role of dermal CD11b-type Langerin 2 DCs in maintaining immunological self-tolerance after UVB exposure. After UVB exposure, dermal CD11b-type Langerin 2 DCs upregulated surface CD86 expression, induced proliferation of Foxp3(+) regulatory T (Treg) cells without exogenous Ags, and upregulated a set of genes associated with immunological tolerance. This Treg-expansion activity was significantly hampered by CD80/CD86 blockade in vivo. These results indicate that CD11b-type Langerin 2 DCs from the UVB-exposed skin are specialized to expand Treg cells in the skin, which suppress autoimmunity.
引用
收藏
页码：119 / 129
页数：11
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