Ultraviolet B-Induced Maturation of CD11b-Type Langerin- Dendritic Cells Controls the Expansion of Foxp3+ Regulatory T Cells in the Skin

被引：28

作者：

Yamazaki, Sayuri ^{[1
]}

Odanaka, Mizuyu ^{[1
]}

Nishioka, Akiko ^{[2
]}

Kasuya, Saori ^{[2
]}

Shime, Hiroaki ^{[1
]}

Hemmi, Hiroaki ^{[3
,4
]}

Imai, Masaki ^{[1
]}

Riethmacher, Dieter ^{[5
,6
]}

Kaisho, Tsuneyasu ^{[3
,4
]}

Ohkura, Naganari ^{[7
,8
]}

Sakaguchi, Shimon ^{[7
]}

Morita, Akimichi ^{[2
]}

机构：

[1] Nagoya City Univ, Dept Immunol, Grad Sch Med Sci, Nagoya, Aichi 4678601, Japan

[2] Nagoya City Univ, Dept Geriatr & Environm Dermatol, Grad Sch Med Sci, Nagoya, Aichi 4678601, Japan

[3] Wakayama Med Univ, Inst Adv Med, Dept Immunol, Wakayama 6418509, Japan

[4] Osaka Univ, World Premier Int Res Ctr Initiat, Immunol Frontier Res Ctr, Lab Immune Regulat, Osaka 5650871, Japan

[5] Nazarbayev Univ, Sch Med, Dept Biomed Sci, Astana 010000, Kazakhstan

[6] Univ Southampton, Sch Med, Southampton SO17 1BJ, Hants, England

[7] Osaka Univ, Dept Expt Immunol, World Premier Int Res Ctr Initiat, Immunol Frontier Res Ctr, Suita, Osaka 5650871, Japan

[8] Osaka Univ, Grad Sch Med, Dept Frontier Res Tumor Immunol, Ctr Med Innovat & Translat Res, Suita, Osaka 5650871, Japan

来源：

JOURNAL OF IMMUNOLOGY | 2018年 / 200卷 / 01期

基金：

日本学术振兴会;

关键词：

EPIDERMAL LANGERHANS CELLS; IN-VIVO; LYMPH-NODE; HOMEOSTASIS; MACROPHAGES; RADIATION; ABLATION; DISTINCT; DIFFERENTIATION; IRRADIATION;

D O I：

10.4049/jimmunol.1701056

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Skin dendritic cells (DCs) are divided into several subsets with distinctive functions. This study shows a previously unappreciated role of dermal CD11b-type Langerin 2 DCs in maintaining immunological self-tolerance after UVB exposure. After UVB exposure, dermal CD11b-type Langerin 2 DCs upregulated surface CD86 expression, induced proliferation of Foxp3(+) regulatory T (Treg) cells without exogenous Ags, and upregulated a set of genes associated with immunological tolerance. This Treg-expansion activity was significantly hampered by CD80/CD86 blockade in vivo. These results indicate that CD11b-type Langerin 2 DCs from the UVB-exposed skin are specialized to expand Treg cells in the skin, which suppress autoimmunity.

引用

页码：119 / 129

页数：11

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