Leukocyte Behavior in Mesenteric Microcirculation upon Experimental By Leishmania Spp. in BALB/c Mice

被引：0

作者：

Neitzke-Abreu, Herintha Coeto ^{[1
,2
]}

Caetano, Rhuan Carlos Souza ^{[3
]}

Reinhold-Castro, KarinRosi ^{[1
]}

Lima-Junior, Manoel Sebastiao da Costa ^{[1
,4
]}

dos Santos, Wagner Jose Tenorio ^{[4
]}

de Melo, Gessilda de Alcantara Nogueira ^{[3
,5
]}

Cuman, Roberto Kenji Nakamura ^{[1
,6
]}

Aristides, Sandra Mara Alessi ^{[1
,3
]}

Silveira, Thais Gomes Verzignassi ^{[1
,3
]}

Lonardoni, Maria Valdrinez Campana ^{[1
,3
,5
]}

机构：

[1] Univ Estadual Maringa, Postgrad Program Hlth Sci, Maringa, PR, Brazil

[2] Fundacao Univ Fed Grande Dourados, Postgrad Program Hlth Sci, Dourados, MS, Brazil

[3] Univ Estadual Maringa, Dept Clin Anal & Biomed, Maringa, PR, Brazil

[4] Oswaldo Cruz Fdn Fiocruz, Aggeu Magalhaes Inst, Dept Immunol, Recife, PE, Brazil

[5] Univ Estadual Maringa, Postgrad Program Biosci & Pathophysiol, Maringa, PR, Brazil

[6] Univ Estadual Maringa, Postgrad Program Pharmaceut Sci, Maringa, PR, Brazil

来源：

IRANIAN JOURNAL OF PARASITOLOGY | 2021年 / 16卷 / 04期

关键词：

Leishmania; Rolling; Cellular adhesion; Leukocyte; MAJOR INFECTION; LYMPH-NODES; NEUTROPHILS; CELLS; INDUCTION; SKIN; GRANULOCYTES; RECRUITMENT; MECHANISMS; RESISTANT;

D O I：

暂无

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Background: We aimed to determine the cellular recruitment (leukocyte rolling and adhesion) by which the Leishmania (Viannia) braziliensis, L. (Leishmania) amazonensis, and L. (Leishmania) major species in the mesenteric microcirculation of BALB/c mice. Methods: Five experimental groups were considered: group 1 (L. braziliensis); group 2 (L. amazonensis); group 3 (L. major); group 4 (control group with PBS); group 5 (negative control group), analyzed 3, 6, 12, and 24 h after parasite inoculation. Results: Infections by the different Leishmania species caused an increase in the number of rolling leukocytes: L. braziliensis a peak at 6 h; L. amazonensis and L. major a peak at 3 h. The Leishmania infections induced leukocyte adhesion: L. major and L. amazonensis showed an increase after 3 and 6 h, respectively. Conclusion: The kinetics of cellular recruitment in Leishmania infections, leading to infection susceptibility or resistance, indicates that distinct mechanisms regulate the initial response to Leishmania infection and determine its course.

引用

页码：567 / 575

页数：9

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