The association of coeliac disease in childhood with functional gastrointestinal disorders: a prospective study in patients fulfilling Rome III criteria

被引:23
作者
Turco, R. [1 ]
Boccia, G. [1 ]
Miele, E. [1 ]
Giannetti, E. [1 ]
Buonavolonta, R. [1 ]
Quitadamo, P. [1 ]
Auricchio, R. [1 ]
Staiano, A. [1 ]
机构
[1] Univ Naples Federico II, Dept Pediat, I-80131 Naples, Italy
关键词
IRRITABLE-BOWEL-SYNDROME; GLUTEN-FREE DIET; QUALITY-OF-LIFE; BACTERIAL GASTROENTERITIS; DEPRESSIVE SYMPTOMS; ENDOSCOPIC FEATURES; POPULATION; ANXIETY; RISK; HISTOPATHOLOGY;
D O I
10.1111/j.1365-2036.2011.04787.x
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background An association between coeliac disease (CD) and functional gastrointestinal disorders (FGIDs) has at present only been demonstrated in adults. Aims To assess the prevalence of FGIDs at 1 year and the role of psychological aspects on the development of FGIDs in CD children. Methods One-hundred consecutive CD children (36M and 64F) were followed up for 1 year. Fifty-six children (25M and 31F) represented the control group. All children and/or their parents completed validated questionnaires for GI symptoms, depression, and anxiety. GI symptoms at diagnosis and after 1 year of gluten-free diet (GFD) were compared. Results Twenty-three/82 (28%) CD patients followed up prospectively, on GFD from at least 1 year, fulfilled the Rome III criteria for FGIDs compared with 5/56 (8.9%) controls (P = 0.008; chi(2) = 6.8; OR: 3.97; 95% CI: 1.40-11.21). Children complaining with GI symptoms alone [21/52 (40.3%)] more likely fulfilled Rome III criteria for FGIDs after 1 year of GFD than children with extra-intestinal symptoms (P = 0.045). CD children with FGDIs presented significantly higher anxiety and depression compared to CD children without FGIDs and controls (P = 0.02). Conclusions This study demonstrates that children with CD on a GFD for a year have a much higher prevalence of functional GI symptoms than do controls. Whether the risk is due to the residua of a chronic inflammatory process, and/or due to psychological factors remains to be further tested.
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页码:783 / 789
页数:7
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