The quest for the holy grail: new antitubercular chemical entities, targets and strategies

被引：50

作者：

Huszar, Stanislav ^{[1
]}

Chibale, Kelly ^{[1
,2
,3
]}

Singh, Vinayak ^{[1
,2
,3
]}

机构：

[1] Univ Cape Town, Drug Discovery & Dev Ctr H3D, ZA-7701 Rondebosch, South Africa

[2] Univ Cape Town, South African Med Res Council, Drug Discovery & Dev Res Unit, Dept Chem, ZA-7701 Rondebosch, South Africa

[3] Univ Cape Town, Inst Infect Dis & Mol Med, ZA-7701 Rondebosch, South Africa

来源：

DRUG DISCOVERY TODAY | 2020年 / 25卷 / 04期

基金：

英国医学研究理事会;

关键词：

KILL MYCOBACTERIUM-TUBERCULOSIS; CELL-WALL CORE; DRUG TARGET; INHIBITION; BIOSYNTHESIS; ETHIONAMIDE; THERAPY; IDENTIFICATION; SPECTINAMIDES; ACTIVATION;

D O I：

10.1016/j.drudis.2020.02.003

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Tuberculosis (TB) remains the leading cause of death from an infectious disease worldwide. TB therapy is complicated by the protracted treatment regimens, development of resistance coupled with toxicity and insufficient sterilizing capacity of current drugs. Although considerable progress has been made on establishing a TB drug pipeline, the high attrition rate reinforces the need to continually replenish the pipeline with high-quality leads that act through inhibition of novel targets. In this review, we highlight some of the key advances that have assisted TB drug discovery with novel chemical matter, targets and strategies - to fuel the TB drug pipeline.

引用

页码：772 / 780

页数：9

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