Calmodulin-dependent protein kinase IV: regulation of function and expression

被引：30

作者：

Krebs, J ^{[1
]}

机构：

[1] ETH Zurich, Inst Biochem 3, CH-8092 Zurich, Switzerland

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 1998年 / 1448卷 / 02期

关键词：

calmodulin; calmodulin kinase IV; calmodulin kinase kinase; thyroid hormone T-3; cAMP response element binding protein; immediate early gene; c-fos; CaMKIV-PP2A complex;

D O I：

10.1016/S0167-4889(98)00142-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Calmodulin-dependent protein kinase IV (CaMKIV) is a key mediator of Ca2+-induced gene expression. This serine/threonine kinase is itself activated by a calmodulin kinase kinase. In the present contribution the gene structure, regulation of activity, the role in Ca2+-dependent gene expression, and the hormonal induction and controlled expression of CaMKIV during tissue development are reviewed. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：183 / 189

页数：7

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