Efficacy of the plantago major L. syrup on radiation induced oral mucositis in head and neck cancer patients: A randomized, double blind, placebo-controlled clinical trial

被引：18

作者：

Soltani, Gholamreza Mohammad ^{[1
]}

Hemati, Simin ^{[2
]}

Sarvizadeh, Mostafa ^{[2
]}

Kamalinejad, Mohammad ^{[3
]}

Tafazoli, Vahid ^{[4
]}

Latifi, Seied AmirHossein ^{[1
]}

机构：

[1] Arak Univ Med Sci, Tradit & Complementary Med Res Ctr TCMRC, Arak, Iran

[2] Isfahan Univ Med Sci, Dept Radiat Oncol, Esfahan, Iran

[3] Shahid Beheshti Univ Med Sci, Sch Pharm, Tehran, Iran

[4] Shiraz Univ Med Sci, Sch Med, Dept Persian Med, Shiraz, Iran

来源：

COMPLEMENTARY THERAPIES IN MEDICINE | 2020年 / 51卷

关键词：

Plantago major L; Mucositis; Cancer; Herbal medicine; Persian medicine; Clinical trial; CHEMOTHERAPY; MANAGEMENT;

D O I：

10.1016/j.ctim.2020.102397

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Introduction: Oral mucositis is a complication of radiation therapy in cancer patients. We designed a trial to evaluate efficacy of plantago major on symptoms of radiation induced mucositis in cancer patients. Methods: In this randomized double blind, placebo-controlled trial 23 patients received plantago major syrup as intervention group and 23 patients received placebo syrup as control group for 7 weeks. Outcome measures were severity of mucositis according to WHO scale and severity of patients' pain assessed by visual analogue scale. Results: Severity of mucositis were significantly lower in intervention group compared to placebo group (p value < 0.05). Also patients in intervention group experienced significantly less pain compared to placebo group during radiotherapy period (p value < 0.05) Conclusion: Plantago major L syrup was effective on the reduction of the symptoms of radiation induced mucositis in patients with head and neck cancers.

引用

页数：5

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