Pleiotropic action of insulin-like peptides of Mollusk, Anodonta cygnea

被引：10

作者：

Shipilov, VN ^{[1
]}

Shpakov, AO ^{[1
]}

Rusakov, YI ^{[1
]}

机构：

[1] RAS, IM Sechenov Evolutionary Physiol & Biochem Inst, St Petersburg 194223, Russia

来源：

TRENDS IN COMPARATIVE ENDOCRINOLOGY AND NEUROBIOLOGY | 2005年 / 1040卷

关键词：

insulin; IGF-I; IRP; mollusk; functions;

D O I：

10.1196/annals.1327.091

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Insulin-related peptides (IRPs) from ganglions of mollusk, Anodonta cygnea, were purified and characterized (IRP1-IRP13) using insulin and insulin-like growth factor-I (IGF-I) radioreceptor test systems. The IRPs were able to bind to insulin and IGF-I receptors. Dose-dependent curve slopes indicated that most IRPs bind with higher affinity to IGF-I receptors than to insulin receptors. The IRP regulatory action on the activity of the adenylyl cyclase signal system showed that these peptides stimulated adenylyl cyclase and GTP-binding activity of G-proteins to the same extent as insulin and IGF-I. The data obtained suggest polyfunctional IRP action that apparently is determined by the molecular structure of individual isoforms.

引用

页码：464 / 465

页数：2