Common Heritable Immunological Variations Revealed in Genetically Diverse Inbred Mouse Strains of the Collaborative Cross

被引：27

作者：

Collin, Roxanne ^{[1
,2
]}

Balmer, Lois ^{[3
,4
,5
]}

Morahan, Grant ^{[3
,4
]}

Lesage, Sylvie ^{[1
,2
]}

机构：

[1] Maisonneuve Rosemont Hosp, Dept Immunol Oncol, Montreal, PQ H1T 2M4, Canada

[2] Univ Montreal, Dept Microbiol Infectiol & Immunol, Montreal, PQ H3C 3J7, Canada

[3] Harry Perkins Inst Med Res, Ctr Diabet Res, Nedlands, WA 6009, Australia

[4] Univ Western Australia, Med Res Ctr, Perth, WA 6000, Australia

[5] Edith Cowan Univ, Sch Med & Hlth Sci, Perth, WA 6027, Australia

来源：

JOURNAL OF IMMUNOLOGY | 2019年 / 202卷 / 03期

基金：

加拿大自然科学与工程研究理事会; 澳大利亚研究理事会; 英国医学研究理事会;

关键词：

QUANTITATIVE TRAIT LOCI; HUMAN IMMUNE-SYSTEM; RAPID IDENTIFICATION; MHC LOCUS; EXPRESSION; GENE; MICE; SUSCEPTIBILITY; ARCHITECTURE; PROPORTION;

D O I：

10.4049/jimmunol.1801247

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Variations in the proportion and number of specific immune cell types among healthy individuals are influenced by both heritable and nonheritable factors. Mouse models, subjected to fewer nonheritable factors than humans, allow the identification of genetic factors that shape the immune system. We characterized immunological trait variability in the Collaborative Cross (CC), a powerful genetic resource of recombinant inbred mouse strains derived from eight diverse founder strains. Of the 18 immunological traits studied in more than 60 CC strains, eight showed genome-wide significant linkage, revealing new genetic loci linked to specific immune traits. We also found that these traits were highly subject to heritable influences. As for humans, mouse immunological traits varied as a continuum rather than as discrete immunophenotypes. The CC thus represents a useful resource to identify factors that determine immunological variations, as well as defining other immune traits likely to be heritable in humans.

引用

页码：777 / 786

页数：10

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