Desymmetrization of meso-bicyclic hydrazines by rhodium-catalyzed enantioselective hydroformylation

被引：17
作者：
Bournaud, Chloee [1 ]
Lecourt, Thomas [1 ]
Micouin, Laurent [1 ]
Meliet, Catherine [2 ]
Agbossou-Niedercorn, Francine [2 ]
机构：
[1] Univ Paris 05, Chim Therapeut Lab, UMR 8638, F-75270 Paris 06, France
[2] Univ Sci & Tech Lille, Unite Catalyse & Chim Solide UMR 8181, ENSCL CHIMIE, F-59652 Villeneuve Dascq, France
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 2008卷 / 13期
关键词：
asymmetric catalysis; hydroformylation; rhodium; N heterocycles;
D O I：
10.1002/ejoc.200800116
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An asymmetric hydroformylation of three meso-bicyclic hydrazines followed by the reduction of the formyl product afforded the corresponding desymmetrized optically enriched hydroxymethyl hydrazines (up to 77.5% ee). ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008).
引用
收藏
页码：2298 / 2302
页数：5
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