Role of insulin-like growth factor-1R system in colorectal carcinogenesis

被引：50

作者：

Donovan, Erin A. ^{[1
]}

Kummar, Shivaani ^{[1
]}

机构：

[1] NCI, Ctr Canc Res, Med Oncol Branch, Bethesda, MD 20892 USA

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2008年 / 66卷 / 02期

基金：

美国国家卫生研究院;

关键词：

anti-IGF therapy; growth factors; acromegaly; epidemiologic studies in cancer;

D O I：

10.1016/j.critrevonc.2007.09.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The insulin-like growth factor (IGF) system is comprised of receptors, ligands (IGF-I and IGF-II), and a family of binding proteins (IGFBPs). It plays an important role in growth and development and in the maintenance of normal homeostasis. We present a review of the current laboratory and epidemiologic evidence that suggests an important role of the IGF system in colorectal carcinogenesis. Due to the complexity of this system, we have focused the review on the role of the IGF-1 receptor and its ligands in colorectal carcinogenesis and the strategies to block this pathway as a potential anti-cancer therapy. Published by Elsevier Ireland Ltd.

引用

页码：91 / 98

页数：8

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