Domino Reaction to Functionalized 2-Hydroxybenzophenones from Electron-Deficient Chromones and 1,3-Dicarbonyl Compounds

被引：27

作者：

Chen, Hong ^{[1
]}

Xie, Fuchun ^{[1
]}

Gong, Jian ^{[1
]}

Hu, Youhong ^{[1
]}

机构：

[1] Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 76卷 / 20期

基金：

中国国家自然科学基金;

关键词：

ONE-POT SYNTHESIS; EFFICIENT APPROACH; TANDEM REACTION; ALDOL REACTIONS; BENZOPHENONES; DERIVATIVES; 3-(1-ALKYNYL)CHROMONES; INHIBITORS; REAGENT; DIENES;

D O I：

10.1021/jo201384f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A base-promoted one-pot tandem reaction sequence has been developed to transform electron-deficient chromone-fused dienes 1 and 1,3-dicarbonyl compounds 2 to functionalized 2-hydroxybenzophenones 3 under mild conditions. This domino process, which involves multiple reactions, including Michael addition/cyclization/elimination, serves as an efficient, economic, and eco-friendly method for the construction of diversified 2-hydroxybenzophenone scaffolds without a transition-metal catalyst and inert atmosphere.

引用

页码：8495 / 8500

页数：6

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