No evidence for distinct types in the evolution of SARS-CoV-2

被引：66

作者：

MacLean, Oscar A. ^{[1
]}

Orton, Richard J. ^{[1
]}

Singer, Joshua B. ^{[1
]}

Robertson, David L. ^{[1
]}

机构：

[1] MRC Univ Glasgow, Ctr Virus Res CVR, Garscube Campus,464 Bearsden Rd, Glasgow G61 1QH, Lanark, Scotland

来源：

VIRUS EVOLUTION | 2020年 / 6卷 / 01期

基金：

英国医学研究理事会;

关键词：

COVID-19; SARS-CoV-2; adaptation; RESPIRATORY SYNDROME CORONAVIRUS; EBOLA-VIRUS; PHYLOGENETIC ANALYSIS; SARS CORONAVIRUS; EPIDEMIC; GENOME;

D O I：

10.1093/ve/veaa034

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A recent study by Tang et al. claimed that two major types of severe acute respiratory syndrome-coronavirus-2 (CoV-2) had evolved in the ongoing CoV disease-2019 pandemic and that one of these types was more `aggressive' than the other. Given the repercussions of these claims and the intense media coverage of these types of articles, we have examined in detail the data presented by Tang et al., and show that the major conclusions of that paper cannot be substantiated. Using examples from other viral outbreaks, we discuss the difficulty in demonstrating the existence or nature of a functional effect of a viral mutation, and we advise against overinterpretation of genomic data during the pandemic.

引用

页数：6

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