Total Synthesis of the Analgesic Conotoxin MrVIB through Selenocysteine-Assisted Folding

被引：70

作者：

de Araujo, Aline Dantas ^{[1
]}

Callaghan, Brid ^{[2
]}

Nevin, Simon T. ^{[3
]}

Daly, Norelle L. ^{[1
]}

Craik, David J. ^{[1
]}

Moretta, Melissa ^{[4
]}

Hopping, Gene ^{[1
]}

Christie, Macdonald J. ^{[4
]}

Adams, David J. ^{[2
]}

Alewood, Paul F. ^{[1
]}

机构：

[1] Univ Queensland, Inst Mol Biosci, St Lucia, Qld 4072, Australia

[2] RMIT Univ, Hlth Innovat Res Inst, Melbourne, Vic 3083, Australia

[3] Univ Queensland, Queensland Brain Inst, St Lucia, Qld 4072, Australia

[4] Univ Sydney, Sydney, NSW 2006, Australia

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 29期

关键词：

disulfides; ion channels; peptides; regioselective folding; selenocysteine; GATED SODIUM-CHANNELS; RECEPTOR ANTAGONISTS; DISELENIDE BRIDGES; POTENT; ANALOGS; PEPTIDES; NA(V)1.8; PAIN; REPLACEMENT; CHEMISTRY;

D O I：

10.1002/anie.201101642

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Secs for your folding problems: Selenocysteine (Sec) residues were used to drive the folding of conotoxin MrVIB, a previously "unfoldable" miniprotein with therapeutic potential (see picture). This simple strategy should generally facilitate the folding of peptides and proteins with multiple disulfide bonds. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：6527 / 6529

页数：3

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