Therapeutic potential of quinazoline derivatives for Alzheimer's disease: A comprehensive review

被引：40
作者：
Haghighijoo, Zahra [1 ]
Zamani, Leila [2 ]
Moosavi, Fatemeh [3 ]
Emami, Saeed [4 ,5 ]
机构：
[1] Univ Louisiana, Dept Chem, Lafayette, LA 70504 USA
[2] Worcester Polytech Inst, 100 Inst Rd, Worcester, MA 01609 USA
[3] Shiraz Univ Med Sci, Med & Nat Prod Chem Res Ctr, Shiraz, Iran
[4] Mazandaran Univ Med Sci, Fac Pharm, Dept Med Chem, Sari, Iran
[5] Mazandaran Univ Med Sci, Fac Pharm, Pharmaceut Sci Res Ctr, Sari, Iran
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2022年 / 227卷
关键词：
Alzheimer's disease; Drug design; Quinazoline; Quinazolinone; AMYLOID-BETA-PEPTIDE; COX-1/2; INHIBITORY-ACTIVITIES; MONOAMINE-OXIDASE INHIBITORS; STRUCTURE-BASED DESIGN; BIOLOGICAL EVALUATION; MOLECULAR DOCKING; ACETYLCHOLINESTERASE INHIBITORS; DYRK1A INHIBITORS; DRUG DEVELOPMENT; BUTYRYLCHOLINESTERASE INHIBITORS;
D O I：
10.1016/j.ejmech.2021.113949
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Quinazolines are considered as a promising class of bioactive heterocyclic compounds with broad properties. Particularly, the quinazoline scaffold has an impressive role in the design and synthesis of new CNS-active drugs. The drug-like properties and pharmacological characteristics of quinazoline could lead to different drugs with various targets. Among CNS disorders, Alzheimer's disease (AD) is a progressive neurodegenerative disorder with memory loss, cognitive decline and language dysfunction. AD is a complex and multifactorial disease therefore, the need for finding multi-target drugs against this devastative disease is urgent. A literature survey revealed that quinazoline derivatives have diverse therapeutic potential for AD as modulators/inhibitors of beta-amyloid, tau protein, cholinesterases, monoamine oxidases, and phosphodiesterases as well as other protective effects. Thus, we describe here the most relevant and recent studies about anti-AD agents with quinazoline structure which can further aid the development and discovery of new anti-AD agents. (C) 2021 Elsevier Masson SAS. All rights reserved.
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页数：34
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