Investigation of antioxidant and anti-inflammatory activities as well as the renal protective potential of green coffee extract in high fat-diet/streptozotocin-induced diabetes in male albino rats

被引：33

作者：

AlAmri, Ohoud D. ^{[1
]}

Albeltagy, Rasha S. ^{[2
]}

Akabawy, Ahmed M. A. ^{[3
]}

Mahgoub, Shahenda ^{[3
]}

Abdel-Mohsen, Doaa M. ^{[3
]}

Moneim, Ahmed E. Abdel ^{[2
]}

Amin, Hatem K. ^{[3
]}

机构：

[1] King Saud Univ, Fac Sci, Dept Zool, Riyadh, Saudi Arabia

[2] Helwan Univ, Fac Sci, Dept Zool & Entomol, Cairo, Egypt

[3] Helwan Univ, Fac Pharm, Dept Biochem & Mol Biol, Cairo, Egypt

来源：

JOURNAL OF FUNCTIONAL FOODS | 2020年 / 71卷

关键词：

High-fat diet; STZ; Green coffee; Renal function; Apoptosis; Inflammation; OXIDATIVE STRESS; CHLOROGENIC ACID; APOPTOSIS; RISK; CONSUMPTION; MECHANISMS; AUTOPHAGY; GLUCOSE; LEVEL; MODEL;

D O I：

10.1016/j.jff.2020.103996

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Green coffee consumption has been stated to have a converse association with type 2 diabetes and metabolic syndrome. Hence, we assessed changes produced by the administration of different doses of green coffee on biomarkers related to renal and antioxidant systems. The study was carried out on 42 diabetic male albino rats; a high-fat diet (HFD) and a single dose of streptozotocin (STZ; 35 mg kg(-1)) were utilized for model induction. Diabetic rats were received green coffee water extract (GCWE; 50 and 100 mg kg(-1)) daily for 28 days. GCWE caused a remarkable recovery of kidney weight, kidney function, and aldosterone level, particularly. Proapoptotic, antiapoptotic and inflammatory markers were significantly improved and showing a great retain to their normal levels specifically in GCWE-treated groups. Also, a marked improvement in the antioxidants defense system was noted. GCWE has a great protective influence on kidney injury of HFD/STZ-induced diabetic rats.

引用

页数：10

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