Palladium(II)-Catalyzed Tandem Oxidative Acetoxylation/ortho C-H Activation/Carbocyclization of Arylallenes

被引：30

作者：

Mazuela, Javier ^{[1
]}

Banerjee, Debasis ^{[1
]}

Backvall, Jan-E. ^{[1
]}

机构：

[1] Stockholm Univ, Arrhenius Lab, Dept Organ Chem, SE-10691 Stockholm, Sweden

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2015年 / 137卷 / 30期

基金：

瑞典研究理事会; 欧洲研究理事会;

关键词：

CARBON BOND FORMATION; ACTIVATED ALKENES; CARBOCYCLIZATION; FUNCTIONALIZATIONS; CARBOHYDROXYLATION; SELECTIVITY; MECHANISM; ARYLATION; OLEFINS; ARENES;

D O I：

10.1021/jacs.5b06068

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein we report an example of tandem. oxidative acetoxylation/carbocyclization of arylallenes 1 using Pd(OAc)(2). The catalytic protocol is highly selective and provides access to new C-C and C-O bonds leading to a carbocyclization. The reaction proceeds via C-H activation by Pd. Mechanistic investigations show that the C-H activation is not the rate-limiting step and indicate that the reaction proceeds via acetoxylation of the allene.

引用

页码：9559 / 9562

页数：4

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