Insight on the Role of Leptin: A Bridge from Obesity to Breast Cancer

被引：12

作者：

Buonaiuto, Roberto ^{[1
]}

Napolitano, Fabiana ^{[1
]}

Parola, Sara ^{[1
]}

De Placido, Pietro ^{[1
]}

Forestieri, Valeria ^{[1
]}

Pecoraro, Giovanna ^{[1
]}

Servetto, Alberto ^{[1
]}

Formisano, Luigi ^{[1
]}

Formisano, Pietro ^{[2
]}

Giuliano, Mario ^{[1
]}

Arpino, Grazia ^{[1
]}

De Placido, Sabino ^{[1
]}

De Angelis, Carmine ^{[1
]}

机构：

[1] Univ Naples Federico II, Dept Clin Med & Surg, I-80131 Naples, Italy

[2] Univ Naples Federico II, Dept Translat Med, I-80131 Naples, Italy

来源：

BIOMOLECULES | 2022年 / 12卷 / 10期

关键词：

leptin; LEPR; obesity; breast cancer; REGULATORY T-CELLS; ADIPOSE-TISSUE; GROWTH-FACTOR; SIGNALING PROMOTES; ENERGY-BALANCE; RECEPTOR; ACTIVATION; EXPRESSION; MICE; MIGRATION;

D O I：

10.3390/biom12101394

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Leptin is a peptide hormone, mainly known for its role as a mediator of adipose tissue endocrine functions, such as appetite control and energy homeostasis. In addition, leptin signaling is involved in several physiological processes as modulation of innate and adaptive immune responses and regulation of sex hormone levels. When adipose tissue expands, an imbalance of adipokines secretion may occur and increasing leptin levels contribute to promoting a chronic inflammatory state, which is largely acknowledged as a hallmark of cancer. Indeed, upon binding its receptor (LEPR), leptin activates several oncogenic pathways, such as JAK/STAT, MAPK, and PI3K/AKT, and seems to affect cancer immune response by inducing a proinflammatory immune polarization and eventually enhancing T-cell exhaustion. In particular, obesity-associated hyperleptinemia has been related to breast cancer risk development, although the underlying mechanism is yet to be completely clarified and needs to be deemed in light of multiple variables, such as menopausal state and immune response. The aim of this review is to provide an overview of the potential role of leptin as a bridge between obesity and breast cancer and to establish the physio-pathological basis of the linkage between these major health concerns in order to identify appropriate and novel therapeutic strategies to adopt in daily clinical practice.

引用

页数：13

共 88 条

[1] Glucose impairs tamoxifen responsiveness modulating connective tissue growth factor in breast cancer cells [J].