The Effect of Interleukin-1 Allele 2 Genotype (IL-1a-889 and IL-1b+3954) on the Individual's Susceptibility to Peri-Implantitis: Case-Control Study

被引:39
作者
Hamdy, Ahmed Abd El-Meguid Mostafa [1 ]
Ebrahem, Mohamed Abd El-Moniem [1 ]
机构
[1] Menia Univ, Fac Dent, Al Minya, Egypt
关键词
IL-1; allele; 2; genotype; peri-implantitis; case-control study; TUMOR-NECROSIS-FACTOR; GINGIVAL CREVICULAR FLUID; GENE POLYMORPHISMS; CHRONIC PERIODONTITIS; BONE-FORMATION; FACTOR-ALPHA; ASSOCIATION; TISSUE; PARAMETERS; SECRETION;
D O I
10.1563/AAID-JOI-D-09-00117.1
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Individuals bearing the combination of interleukin (IL)-1 allele 2 at IL-1A(-889) and IL-1B(+3954) are referred to as being genotype positive and are susceptible to increased periodontal tissue destruction. The aim of this study was to assess the possible association of IL-1 allele 2 (IL-1A(-889) and IL-B+3954) genotypes with the severity of peri-implantitis progression and the effect of this combination on treatment outcomes. Fifty patients with International Team for Implantology implants were studied; patients ranged in age from 35-55 years, and each patient had 1 implant. According to pen-implant tissue status, patients were divided into 2 groups: group I consisted of 25 patients with peri-implantitis, and group II comprised 25 patients with healthy pen-implant tissue. Clinical parameters were assessed at baseline and after 3 and 6 months. Epithelial cells were collected from the oral mucosa by plastic spatula and were used for IL-1 genotyping by the polymerase chain reaction technique. Group I patients were subjected to a peri-implantitis treatment and maintenance program. In all, 17 patients from group I and 5 patients from group II were genotype positive, with a statistically significant difference noted between the 2 groups. Group I genotype-positive patients presented with higher scores and measurements of clinical parameters with increased suppuration from pen-implant tissues compared with group II; differences were statistically significant (P < .05). In terms of response to treatment, genotype-negative patients demonstrated better response than genotype-positive patients. The combination of IL-1 allele 2 (IL-1A(-889) and IL-1B(+3954)) in patients with inflamed periodontal or pen-implant tissues acts as a risk factor that leads to greater tissue destruction. IL-1 gene polymorphism at IL-1A(-889) and IL-1B(+3954) may affect outcomes of treatment for peri-implantitis in genotype-positive individuals.
引用
收藏
页码:325 / 334
页数:10
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