Individuals bearing the combination of interleukin (IL)-1 allele 2 at IL-1A(-889) and IL-1B(+3954) are referred to as being genotype positive and are susceptible to increased periodontal tissue destruction. The aim of this study was to assess the possible association of IL-1 allele 2 (IL-1A(-889) and IL-B+3954) genotypes with the severity of peri-implantitis progression and the effect of this combination on treatment outcomes. Fifty patients with International Team for Implantology implants were studied; patients ranged in age from 35-55 years, and each patient had 1 implant. According to pen-implant tissue status, patients were divided into 2 groups: group I consisted of 25 patients with peri-implantitis, and group II comprised 25 patients with healthy pen-implant tissue. Clinical parameters were assessed at baseline and after 3 and 6 months. Epithelial cells were collected from the oral mucosa by plastic spatula and were used for IL-1 genotyping by the polymerase chain reaction technique. Group I patients were subjected to a peri-implantitis treatment and maintenance program. In all, 17 patients from group I and 5 patients from group II were genotype positive, with a statistically significant difference noted between the 2 groups. Group I genotype-positive patients presented with higher scores and measurements of clinical parameters with increased suppuration from pen-implant tissues compared with group II; differences were statistically significant (P < .05). In terms of response to treatment, genotype-negative patients demonstrated better response than genotype-positive patients. The combination of IL-1 allele 2 (IL-1A(-889) and IL-1B(+3954)) in patients with inflamed periodontal or pen-implant tissues acts as a risk factor that leads to greater tissue destruction. IL-1 gene polymorphism at IL-1A(-889) and IL-1B(+3954) may affect outcomes of treatment for peri-implantitis in genotype-positive individuals.
机构:
Univ Queensland, Sch Dent, Oral Care Res Programme, Brisbane, Qld 4072, AustraliaUniv Queensland, Sch Dent, Oral Care Res Programme, Brisbane, Qld 4072, Australia
Cullinan, MP
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Westerman, B
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机构:Univ Queensland, Sch Dent, Oral Care Res Programme, Brisbane, Qld 4072, Australia
Westerman, B
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Hamlet, SM
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机构:Univ Queensland, Sch Dent, Oral Care Res Programme, Brisbane, Qld 4072, Australia
Hamlet, SM
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Palmer, JE
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机构:Univ Queensland, Sch Dent, Oral Care Res Programme, Brisbane, Qld 4072, Australia
Palmer, JE
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Faddy, MJ
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机构:Univ Queensland, Sch Dent, Oral Care Res Programme, Brisbane, Qld 4072, Australia
Faddy, MJ
;
Lang, NP
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机构:Univ Queensland, Sch Dent, Oral Care Res Programme, Brisbane, Qld 4072, Australia
Lang, NP
;
Seymour, GJ
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机构:Univ Queensland, Sch Dent, Oral Care Res Programme, Brisbane, Qld 4072, Australia
机构:
Univ Queensland, Sch Dent, Oral Care Res Programme, Brisbane, Qld 4072, AustraliaUniv Queensland, Sch Dent, Oral Care Res Programme, Brisbane, Qld 4072, Australia
Cullinan, MP
;
Westerman, B
论文数: 0引用数: 0
h-index: 0
机构:Univ Queensland, Sch Dent, Oral Care Res Programme, Brisbane, Qld 4072, Australia
Westerman, B
;
Hamlet, SM
论文数: 0引用数: 0
h-index: 0
机构:Univ Queensland, Sch Dent, Oral Care Res Programme, Brisbane, Qld 4072, Australia
Hamlet, SM
;
Palmer, JE
论文数: 0引用数: 0
h-index: 0
机构:Univ Queensland, Sch Dent, Oral Care Res Programme, Brisbane, Qld 4072, Australia
Palmer, JE
;
Faddy, MJ
论文数: 0引用数: 0
h-index: 0
机构:Univ Queensland, Sch Dent, Oral Care Res Programme, Brisbane, Qld 4072, Australia
Faddy, MJ
;
Lang, NP
论文数: 0引用数: 0
h-index: 0
机构:Univ Queensland, Sch Dent, Oral Care Res Programme, Brisbane, Qld 4072, Australia
Lang, NP
;
Seymour, GJ
论文数: 0引用数: 0
h-index: 0
机构:Univ Queensland, Sch Dent, Oral Care Res Programme, Brisbane, Qld 4072, Australia