Advances in the Biological Functions and Mechanisms of miRNAs in the Development of Osteosarcoma

被引：22
作者：
Dong, Zihe [1 ]
Liao, Zhipeng [2 ]
He, Yonglin [1 ]
Wu, Chengye [1 ]
Meng, Zixiang [1 ]
Qin, Baolong [1 ]
Xu, Ge [1 ]
Li, Zeyang [1 ]
Sun, Tianxin [1 ]
Wen, Yuyan [1 ]
Li, Guangjie [3 ]
机构：
[1] Lanzhou Univ, Sch Clin Med 1, Lanzhou, Gansu, Peoples R China
[2] Lanzhou Univ, Sch Clin Med 2, Lanzhou, Gansu, Peoples R China
[3] Lanzhou Univ, Hosp 1, Lanzhou, Gansu, Peoples R China
来源：
TECHNOLOGY IN CANCER RESEARCH & TREATMENT | 2022年 / 21卷
关键词：
microRNAs; osteosarcoma; biomarkers; targeted therapy; molecular mechanisms; GROWTH-FACTOR-BETA; INHIBITS CELL-PROLIFERATION; PROGNOSTIC-FACTORS; WNT/BETA-CATENIN; HEPATOCELLULAR-CARCINOMA; TUMOR-GROWTH; SUPPRESSES PROLIFERATION; MOLECULAR-MECHANISMS; REGULATES AUTOPHAGY; MICRORNA BIOGENESIS;
D O I：
10.1177/15330338221117386
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Osteosarcoma is one of the most common primary malignant bone tumors, mainly occurring in children and adolescents, and is characterized by high morbidity and poor prognosis. MicroRNAs, a class of noncoding RNAs consisting of 19 to 25 nucleotides, are involved in cell proliferation, invasion, metastasis, and apoptosis to regulate the development and progression of osteosarcoma. Studies have found that microRNAs are closely related to the diagnosis, treatment, and prognosis of osteosarcoma patients and have an important role in improving drug resistance in osteosarcoma. This paper reviews the role of microRNAs in the pathogenesis of osteosarcoma and their clinical value, aiming to provide a new research direction for diagnosing and treating osteosarcoma and achieving a better prognosis.
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页数：16
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