Matrix-assisted laser desorption/ionisation, an experience

被引：91

作者：

Hillenkamp, F ^{[1
]}

Karas, M ^{[1
]}

机构：

[1] Univ Munster, Inst Med Phys & Biophys, D-48149 Munster, Germany

来源：

INTERNATIONAL JOURNAL OF MASS SPECTROMETRY | 2000年 / 200卷 / 1-3期

关键词：

MALDI; LAMMA; mass spectrometry; time-of-right; TOF; laser desorption;

D O I：

10.1016/S1387-3806(00)00300-6

中图分类号：

O64 [物理化学（理论化学）、化学物理学]; O56 [分子物理学、原子物理学];

学科分类号：

070203 ; 070304 ; 081704 ; 1406 ;

摘要：

MALDI, matrix-assisted laser desorption/ionisation has been a success, no doubt. Together with ESI, electrospray ionization it has revolutionized the analysis of macromolecules from identification to function, the former a key element, e.g. in proteomics, the latter partially still a dream, a not so unrealistic one, though. Thousands of MALDI instruments can be found in research as well as in industrial laboratories all around the globe and even more scientists and developers find it useful in the pursuit of their diverse projects. Once discussed in little attended sessions outside the prime time it is now one of the centers of attention and discussion in literally all conferences on mass spectrometry and increasingly so also on bioanalytics. Yes, MALDI has come of age! (C) 2000 Elsevier Science B.V.

引用

页码：71 / 77

页数：7

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