Hepatitis B vaccination and central nervous system demyelination: an immunological approach

被引：17
作者：
Piaggio, E
Younes, AB
Desbois, S
Gout, O
Tourbah, A
Lyon-Caen, O
Liblau, RS
机构：
[1] Purdue Univ Hosp, INSERM, U563, F-31000 Toulouse, France
[2] Salpetriere Univ Hosp, INSERM, U546, Paris, France
[3] Salpetriere Univ Hosp, Dept Neurol, Paris, France
[4] Rangueil Univ Hosp, Immunol Lab, Toulouse, France
来源：
JOURNAL OF AUTOIMMUNITY | 2005年 / 24卷 / 01期
关键词：
CNS demyelination; hepatitis B vaccination; IFN-gamma; IL-5; multiple sclerosis;
D O I：
10.1016/j.jaut.2004.11.007
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Demyelination events or multiple sclerosis following hepatitis B virus (HBV) vaccination have been reported. We therefore compared the T-cell response to HBsAg in patients with CNS demyelination following HBV vaccination and in HBV-vaccinated healthy individuals. Our data showed no differences in terms of T-cell proliferation or cytokine production between these groups and may help to allay concerns that HBV vaccination might trigger a deleterious immune response. (c) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：33 / 37
页数：5
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