The contributions of lesion laterality and lesion volume to decision-making impairment following frontal lobe damage

被引:248
作者
Clark, L
Manes, F
Nagui, A
Sahakian, BJ
Robbins, TW
机构
[1] Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England
[2] Raul Carrea Inst Neurol Res, Cognit Neurol Div, Buenos Aires, DF, Argentina
[3] Addenbrookes Hosp, Dept Radiol, Cambridge CB2 2QQ, England
[4] Univ Cambridge, Addenbrookes Hosp, Sch Clin Med, Dept Psychiat, Cambridge CB2 2QQ, England
基金
英国惠康基金;
关键词
risk-taking; orbitofrontal; neuropsychology; impulsivity;
D O I
10.1016/S0028-3932(03)00081-2
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Lesions to prefrontal cortex (PFC) in humans can severely disrupt everyday decision-making, with concomitant effects on social and occupational functioning. Forty-six patients with unilateral lesions to prefrontal cortex and 21 healthy control subjects were administered three neuropsychological measures of decision-making: the Iowa Gambling Task, the Cambridge Gamble Task, and the Risk Task. Magnetic resonance imaging (MRI) scans were acquired from 40 patients, with region of interest (ROI) mapping of prefrontal subregions. The frontal patients showed only limited damage in medial and orbital prefrontal cortex, but greater damage in lateral prefrontal regions of interest. Patients with right frontal lesions prefer-red the risky decks on the Iowa Gambling Task, and differed significantly from left frontal and control subjects. Within the right frontal group, the preference for the risky decks was correlated with the total lesion volume and the volume of damage outside of the ventromedial prefrontal region. Right and left frontal groups did not differ significantly on the Cambridge Gamble Task or the Risk Task, and performance was not associated with lesion volume. The results indicate a laterality effect on the Iowa Gambling Task, and the contribution of prefrontal regions outside the ventromedial region to task performance. The Cambridge Gamble Task and Risk Task were less sensitive to the effects of unilateral frontal lobe lesions, and may be more selectively associated with ventral prefrontal damage. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:1474 / 1483
页数:10
相关论文
共 25 条
[1]   Stop-signal inhibition disrupted by damage to right inferior frontal gyrus in humans [J].
Aron, AR ;
Fletcher, PC ;
Bullmore, ET ;
Sahakian, BJ ;
Robbins, TW .
NATURE NEUROSCIENCE, 2003, 6 (02) :115-116
[2]  
Bechara A, 1998, J NEUROSCI, V18, P428
[3]   INSENSITIVITY TO FUTURE CONSEQUENCES FOLLOWING DAMAGE TO HUMAN PREFRONTAL CORTEX [J].
BECHARA, A ;
DAMASIO, AR ;
DAMASIO, H ;
ANDERSON, SW .
COGNITION, 1994, 50 (1-3) :7-15
[4]   Spatial normalization of brain images with focal lesions using cost function masking [J].
Brett, M ;
Leff, AP ;
Rorden, C ;
Ashburner, J .
NEUROIMAGE, 2001, 14 (02) :486-500
[5]  
Damasio A. R., 1994, DESCARTES ERROR EMOT
[6]   Decision-making in a risk-taking task: A PET study [J].
Ernst, M ;
Bolla, K ;
Mouratidis, M ;
Contoreggi, C ;
Matochik, JA ;
Kurian, V ;
Cadet, JL ;
Kimes, AS ;
London, ED .
NEUROPSYCHOPHARMACOLOGY, 2002, 26 (05) :682-691
[7]   SEVERE DISTURBANCE OF HIGHER COGNITION AFTER BILATERAL FRONTAL-LOBE ABLATION - PATIENT EVR [J].
ESLINGER, PJ ;
DAMASIO, AR .
NEUROLOGY, 1985, 35 (12) :1731-1741
[8]   Right hemispheric dominance of inhibitory control: An event-related functional MRI study [J].
Garavan, H ;
Ross, TJ ;
Stein, EA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (14) :8301-8306
[9]  
Gregory CA, 1996, J NEURAL TRANSM-SUPP, P103
[10]  
Howell D.C., 2006, STAT METHODS PSYCHOL, V6th