Photoredox-Catalyzed Bromodifluoromethylation of Alkenes with (Difluoromethyl)triphenylphosphonium Bromide

被引：155

作者：

Lin, Qing-Yu ^{[1
]}

Ran, Yang ^{[1
]}

Xu, Xiu-Hua ^{[1
]}

Qing, Feng-Ling ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, 345 Lingling Lu, Shanghai 200032, Peoples R China

[2] Donghua Univ, Coll Chem Chem Engn & Biotechnol, 2999 North Renmin Lu, Shanghai 201620, Peoples R China

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 10期

基金：

中国国家自然科学基金;

关键词：

COPPER-MEDIATED DIFLUOROMETHYLATION; ELECTRON-DEFICIENT ALKENES; VISIBLE-LIGHT; UNACTIVATED ALKENES; FLUOROALKYLSULFONYL CHLORIDES; BIOLOGICAL EVALUATION; N-ARYLACRYLAMIDES; SP(3) CARBON; TRIFLUOROMETHYLATION; REAGENTS;

D O I：

10.1021/acs.orglett.6b00935

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Under visible-light photoredox conditions, difluoromethyltriphenylphosphonium bromide was used as the precursor of the CF2H radical for bromodifluoromethylation of alkenes. The presence of catalytic CuBr2 resulted in the selective formation of the bromodifluoromethylated products.

引用

页码：2419 / 2422

页数：4

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