Comparative virulence of three species of Exophiala in mice

被引：4

作者：

Calvo, Enrique ^{[1
]}

Mar Rodriguez, M. ^{[1
]}

Marine, Marcal ^{[1
]}

Mayayo, Emilio ^{[1
]}

Javier Pastor, F. ^{[1
]}

Guarro, Josep ^{[1
]}

机构：

[1] Univ Rovira & Virgili, Unitat Microbiol, Fac Med, E-43201 Reus, Spain

来源：

MEDICAL MYCOLOGY | 2010年 / 48卷 / 06期

关键词：

Phaeohyphomycosis; Exophiala; animal models; COLONY-STIMULATING FACTOR; WANGIELLA-DERMATITIDIS; DISSEMINATED PHEOHYPHOMYCOSIS; CEREBRAL PHEOHYPHOMYCOSIS; OLIGOSPERMA; THERAPY;

D O I：

10.3109/13693780903582481

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The virulence of Exophiala dermatitidis, E. oligosperma and E. xenobiotica, three of the most common members of the genus that cause human infections, was evaluated using experimental models of disseminated infection in immunocompromised mice. Exophiala dermatitidis, and to a lesser extent E. oligosperma, were the two species causing the highest mortality, while mice infected with E. xenobiotica had the lowest mortality. Tissue burden and histopathology studies demonstrated the neurotropism of E. dermatitidis, while E. oligosperma and E. xenobiotica had a limited capacity for invading brain tissue. These models could be useful for testing new therapies against Exophiala infections.

引用

页码：853 / 857

页数：5

共 20 条

[1] Catheter-assosiated fungemia due to Exophiala oligosperma in a leukemic child and review of fungemia cases cause by Exophiala species
Al-Obaid, I.
Ahmad, S.
Khan, Z. U.
Dinesh, B.
Hejab, H. M.
[J]. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2006, 25 (11) : 729 - 732
[2] Subcutaneous phaeohyphomycosis caused by Exophiala xenobiotica in a non-Hodgkin lymphoma patient
Aoyama, Yumi
Nomura, Masayo
Yamanaka, Shinya
Ogawa, Yoko
Kitajima, Yasuo
[J]. MEDICAL MYCOLOGY, 2009, 47 (01) : 95 - 99
[3] Exophiala oligosperma causing olecranon bursitis
Bossler, AD
Richter, SS
Chavez, AJ
Vogelesang, SA
Sutton, DA
Grooters, AM
Rinaldi, MG
de Hoog, GS
Pfaller, MA
[J]. JOURNAL OF CLINICAL MICROBIOLOGY, 2003, 41 (10) : 4779 - 4782
[4] Acute cerebral phaeohyphomycosis due to Wangiella dermatitidis accompanied by cerebrospinal fluid eosinophilia
Chang, CL
Kim, DS
Park, DJ
Kim, HJ
Lee, CH
Shin, JH
[J]. JOURNAL OF CLINICAL MICROBIOLOGY, 2000, 38 (05) : 1965 - 1966
[5] Exophiala xenobiotica sp nov., an opportunistic black yeast inhabiting environments rich in hydrocarbons
De Hoog, G. S.
Zeng, J. S.
Harrak, M. J.
Sutton, D. A.
[J]. ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY, 2006, 90 (03): : 257 - 268
[6] Species diversity and polymorphism in the Exophiala spinifera clade containing opportunistic black yeast-like fungi
de Hoog, GS
Vicente, V
Caligiorne, RB
Kantarcioglu, S
Tintelnot, K
van den Ende, AHGG
Haase, G
[J]. JOURNAL OF CLINICAL MICROBIOLOGY, 2003, 41 (10) : 4767 - 4778
[7] DIXON DM, 1987, J MED VET MYCOL, V25, P97
[8] DIXON DM, 1989, J MED VET MYCOL, V27, P335
[9] Antifungal susceptibility testing of Exophiala spp.: a head-to-head comparison of amphotericin B, itraconazole, posaconazole and voriconazole
Fothergill, Annette W.
Rinaldi, Michael G.
Sutton, Deanna A.
[J]. MEDICAL MYCOLOGY, 2009, 47 (01) : 41 - 43
[10] Subcutaneous phaeohyphomycosis caused by Exophiala oligosperma in a renal transplant recipient
Gonzalez-Lopez, M. A.
Salesa, R.
Gonzalez-Vela, M. C.
Fernandez-Llaca, H.
Val-Bernal, J. F.
Cano, J.
[J]. BRITISH JOURNAL OF DERMATOLOGY, 2007, 156 (04) : 762 - 764

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