Comparative virulence of three species of Exophiala in mice

被引：4

作者：

Calvo, Enrique ^{[1
]}

Mar Rodriguez, M. ^{[1
]}

Marine, Marcal ^{[1
]}

Mayayo, Emilio ^{[1
]}

Javier Pastor, F. ^{[1
]}

Guarro, Josep ^{[1
]}

机构：

[1] Univ Rovira & Virgili, Unitat Microbiol, Fac Med, E-43201 Reus, Spain

来源：

MEDICAL MYCOLOGY | 2010年 / 48卷 / 06期

关键词：

Phaeohyphomycosis; Exophiala; animal models; COLONY-STIMULATING FACTOR; WANGIELLA-DERMATITIDIS; DISSEMINATED PHEOHYPHOMYCOSIS; CEREBRAL PHEOHYPHOMYCOSIS; OLIGOSPERMA; THERAPY;

D O I：

10.3109/13693780903582481

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The virulence of Exophiala dermatitidis, E. oligosperma and E. xenobiotica, three of the most common members of the genus that cause human infections, was evaluated using experimental models of disseminated infection in immunocompromised mice. Exophiala dermatitidis, and to a lesser extent E. oligosperma, were the two species causing the highest mortality, while mice infected with E. xenobiotica had the lowest mortality. Tissue burden and histopathology studies demonstrated the neurotropism of E. dermatitidis, while E. oligosperma and E. xenobiotica had a limited capacity for invading brain tissue. These models could be useful for testing new therapies against Exophiala infections.

引用

页码：853 / 857

页数：5

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