[3H]RX 821002 in human dorsolateral prefrontal cortex:: no changes in postmortem tissue from subjects with schizophrenia

被引：4

作者：

Dean, B

机构：

[1] Mental Hlth Res Inst Victoria, Rebecca L Cooper Res Labs, Parkville, Vic 3052, Australia

[2] Monash Univ, Dept Psychol Med, Clayton, Vic 3168, Australia

[3] Univ Melbourne, Dept Psychiat, Parkville, Vic 3052, Australia

来源：

PSYCHIATRY RESEARCH | 2003年 / 119卷 / 1-2期

关键词：

alpha(2)-adrenoreceptors; Brodmann's area 9; clozapine; olanzapine; schizophrenia; ALPHA(2)-ADRENOCEPTOR SUBTYPES; HUMAN-BRAIN; RECEPTORS; OLANZAPINE; DOPAMINE; VICTIMS; BINDING;

D O I：

10.1016/S0165-1781(03)00108-2

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

One of the major differences between the atypical antipsychotic drugs clozapine and olanzapine is that clozapine has a two-fold higher affinity for the alpha(2)-adrenoreceptors. As clozapine can have therapeutic benefits in individuals that do not respond to other antipsychotic drugs, this raises the possibility that changes in the a2-adrenoreceptors could be a marker for a predisposition to treatment resistance. A methodology has been optimised to measure the binding of [H-3]RX 821002 to alpha(2)-adrenoreceptors in human postmortem CNS and has shown that these receptors are not altered in Brodmann's area 9 from subjects with schizophrenia. These data add to those of one other study that showed the alpha(2)-adrenoreceptors were not altered in Brodmann's area 10 and the hippocampus from subjects with schizophrenia, and do not support the hypothesis that changes in alpha(2)-adrenoreceptors are a marker for treatment resistance in schizophrenia. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：25 / 31

页数：7

共 22 条

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